An interventional study of Carbohydrate loading before surgery in Heart Surgery and Ischemic Heart Disease, sponsored by Damascus University. Recruiting at 1 site in Syria. Per ClinicalTrials.gov, last updated 2026-09-01.
Sponsored by Damascus University · Not applicable, Interventional, and Supportive care
Enhanced recovery after surgery protocols aim to optimize perioperative care and improve surgical outcomes. Preoperative carbohydrate loading has demonstrated benefits in reducing insulin resistance and improving patient outcomes. While non-diabetic patients benefit from this approach, its efficacy in diabetic type 2 patients undergoing CABG remains less understood. This study aims to address this gab by evaluating the physiological and clinical outcomes for carbohydrate loading in this specific population.
A randomized controlled trial comparing diabetic type 2 patients receiving carbohydrate loading with those undergoing traditional fasting protocols. Patients will be randomized to two groups; group (a) patients will have carbohydrate loading 2 hours before the surgery (400 ml of 12.5 maltodextrin and 400 ml of over-the-counter fruit-based lemonade), while group (b) patients (control group) will have standard fasting protocol 8 hours before surgery.
Aims of the study:
1,123 studies on the registry are indexed under Myocardial Ischemia; 177 are open to participants now.
This study's planned enrollment of 50 is below the median of 116 across 622 interventional studies indexed under Myocardial Ischemia.
Browse Myocardial Ischemia studies →Damascus University is the lead sponsor of 212 studies on the registry; 11 are open to participants now.
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All diabetic type 2 patients undergoing isolated on-pump coronary artery bypass surgery.
Exclusion Criteria:
Patients who will have carbohydrate loading 2 hours before the surgery (400 ml of 12.5 maltodextrin and 400 ml of over-the-counter fruit-based lemonade)
Dietary Supplement: Carbohydrate loading before surgery
Patients who will have standard fasting protocol 8 hours before surgery
Carbohydrate loading 2 hours before the surgery (400 ml of 12.5 maltodextrin and 400 ml of over-the-counter fruit-based lemonade)
Short Insulin Tolerance Test (KITT)
Short Insulin Tolerance Test (KITT) will test changes in insulin tolerance postoperatively
Time frame: Preoperatively and up to 72 hours postoperatively
CRP levels
C-Reactive Protein levels in the blood
Time frame: Preoperatively and up to 72 hours postoperatively
Arterial blood gases
Changes in arterial blood gases
Time frame: Preoperatively and up to 72 hours postoperatively
Operative time
Total operative time, skin-to-skin
Time frame: Intraoperatively, skin-to-skin
CPB duration
Total time spend using cardiopulmonary bypass perfusion
Time frame: Intraoperatively, using extracorporeal circulation
Blood loss
Blood loss and blood product usage
Time frame: Intraoperatively and up to 72 hours postoperatively
Number of grafts performed
Number of grafts performed during the operation
Time frame: Intraoperatively, skin-to-skin
Use of inotrops
Use of inotrops to support the cardiac output
Time frame: Intraoperatively and up to 72 hours postoperatively
Complications
All perioperative complications
Time frame: Intraoperatively and up to 72 hours postoperatively
Plan to share: Yes — All IPD will be uploaded on a data sharing platform
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report, Analytic code
Time frame: December 31, 2026, and will be available permanently
Access criteria: IPD will be open to all through a data sharing platform
Ran from Apr 2025 to primary completion in Apr 2026, 12 months.
Of 155 non-industry interventional studies with no phase under Myocardial Ischemia, half reached primary completion within 33 months of starting (the median), counting those still running; a quarter within 15 and three quarters within 56. This study's 12 months is below that.
Counting every sponsor, half of 192 studies reached it within 34 months; a quarter within 15 and three quarters within 58.
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