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Active, not recruitingNCT06891196Updated Apr 3, 2026

Mixed-Methods Evaluation of Short-, Medium-, and Long-Term Outcomes Following Hip Treatment

An observational study in Hip Dysplasia, Legg-Calvâe-Perthes Disease and Avascular Necrosis of Hip, sponsored by Mayo Clinic. Active, not recruiting at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-03.

Sponsored by Mayo Clinic · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
500
Ages
18 Years and older
Sex
All
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Study summary

This study, titled "Mixed-Methods Evaluation of Short-, Medium-, and Long-Term Outcomes Following Hip Treatment," aims to assess the long-term effectiveness of treatments for pediatric hip conditions, including hip dysplasia, Legg-Calve-Perthes disease, SCFE, and avascular necrosis.

Read the detailed description

Conducted at Mayo Clinic, the study combines retrospective chart reviews and prospective follow-up to gather data on clinical outcomes, radiographic measures, and patient-reported outcomes (PROs) like functional status, pain, and quality of life.

The retrospective component analyzes records from 1975 to 2024, while the prospective component includes follow-up surveys using validated PRO measures (e.g., HOOS, SF-12, VAS). This study seeks to identify recurrence rates and complications associated with hip treatments, providing insights to improve future care standards for pediatric hip conditions. Data will be securely stored, with confidentiality maintained throughout.

02

Conditions studied

  • Hip Dysplasia
  • Legg-Calvâe-Perthes Disease
  • Avascular Necrosis of Hip

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03

In context

Hip Dislocation

107 studies on the registry are indexed under Hip Dislocation; 36 are open to participants now.

This study's planned enrollment of 500 is above the median of 120 across 39 observational studies indexed under Hip Dislocation.

Browse Hip Dislocation studies →

Lead sponsor

Mayo Clinic is the lead sponsor of 3,269 studies on the registry; 672 are open to participants now.

Of its 452 completed or terminated interventional studies of FDA-regulated products, 321 (71%) have results posted.

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Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Patients over the age of 18 seen for a concern of hip pathology at Mayo between 1975 and 2024.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients over the age of 18 seen for a concern of hip pathology at Mayo between 1975 and 2024
  • Patients over 18 who can be contacted for follow-up and are willing to participate.

Exclusion criteria

Exclusion Criteria:

  • Patients presenting over age 18 for hip dysplasia
  • Patients who are unwilling to complete follow up surveys.
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
500 participants (estimated)
Patient registry
No

Groups and cohorts

  • Pediatric patients with hip conditions

    Medical records and radiographs of patients who were treated for hip conditions at Mayo Clinic from 1975 to 2022 will be included in a retrospective chart review. Radiographic evaluations will include measurements of the neck-shaft angle, acetabular index, migration index, and other commonly used metrics. The prospective follow-up will include a subset of patients from the retrospective review, who will be complete long-term follow-up surveys.

    Other: Long-term Follow-up Surveys

Interventions

  • OtherLong-term Follow-up Surveys

    Patients will be given surveys, including validated PRO measures such as the Hip Disability and Osteoarthritis Outcomes Score (HOOS), Short-Form 12 (SF-12), Visual Analog Scale (VAS) for pain, and Marx activity scores.

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What researchers measure

Primary outcomes

  1. Revision surgery

    Total number of patients who required revision surgery for pediatric hip conditions

    Time frame: 2 years

Secondary outcomes

  1. Change in neck-shaft angle measurement

    Radiographic measurement of the neck-shaft angle

    Time frame: Baseline, 2 years

  2. Change in acetabular index

    Radiographic measurement of the acetabular index

    Time frame: Baseline, 2 years

  3. Change in migration index

    Radiographic measurement of the migration index

    Time frame: Baseline, 2 years

07

Study locations

1 site
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Jan 2025 (actual). Primary completion is estimated for Jan 2027, 24 months after the start.

Of 20 observational studies under Hip Dislocation, half reached primary completion within 83 months of starting (the median), counting those still running; a quarter within 41 and three quarters within 113. This study's planned 24 months is below that.

How these figures are worked out, and which studies are left out of them.

Registered
Feb 19, 2025
First posted
Mar 24, 2025
StartActual
Jan 15, 2025
Primary completionEst.
Jan 15, 2027
CompletionEst.
Jan 15, 2027
Last update
Apr 3, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 3, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06891196
Lead sponsor
Mayo Clinic
Responsible party
Emmanouil Grigoriou (Principal Investigator, Mayo Clinic) — Principal investigator
First posted
Mar 24, 2025
Start date
Jan 15, 2025
Primary completion
Jan 15, 2027 (estimated)
Completion
Jan 15, 2027 (estimated)
Last update
Apr 3, 2026

Study contacts

Emmanouil Grigoriou, M.D.
principal investigator · Mayo Clinic

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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