ClinicalTrials.gg
RecruitingNCT06853301E-MOCUpdated Jul 22, 2026

Machine Learning Assisted Electrochemical Profiling to Provide Early Identification of Bloodstream Infections Pathogens

An interventional study of Blood culture sampling in Bacteremia Sepsis, sponsored by University Hospital, Grenoble. Recruiting at 2 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-22.

Sponsored by University Hospital, Grenoble · Not applicable, Interventional, and Diagnostic

From the registry’s dates

  • Started Jul 2026; still recruiting 3 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
200
Allocation
Not applicable
Ages
18 Years and older
Sex
All
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Study summary

In the context of a bacteremia, although significant progress has been made in speeding up pathogen identification once a blood culture bottle turns positive, few cost-effective solutions have been proposed to improve the earlier stages of the process-specifically, from blood collection to bottle positivity. The investigators propose that transport time could be leveraged to grow and identify bacteria, enabling faster access to actionable results through innovative technologies. This project aims to develop a bacterial identification database by analyzing the electrochemical profile of bacteria growing within the blood culture bottle, using machine learning.

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Conditions studied

  • Bacteremia Sepsis

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Keywords

  • Rapid identification
  • Positive blood culture
  • Electrochemical profiling
  • Machine learning
  • Artificial intelligence
  • Bacteremia
  • Database
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In context

Bacteremia

297 studies on the registry are indexed under Bacteremia; 51 are open to participants now.

This study's planned enrollment of 200 is above the median of 156 across 156 interventional studies indexed under Bacteremia.

Browse Bacteremia studies →

Lead sponsor

University Hospital, Grenoble is the lead sponsor of 837 studies on the registry; 207 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • patient requiring a blood culture sample as standard of care procedure
  • body weight > 50 Kg
  • Patient for whom the collection of 2 to 4 additional blood culture bottles is feasible, depending on venous access
  • patient who has not objected to participation in the project

Exclusion criteria

Exclusion Criteria:

  • Patient protected under the French Public Health Code (pregnant or breastfeeding women, patients under guardianship or curatorship, hospitalized under constraint, or deprived of liberty)
  • patients with ongoing antibiotic treatment at the time of sampling
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Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
200 participants (estimated)

Study arms

  • Experimental
    Patients

    Patients with blood culture sampling as standard of care. Two to four additional blood culture bottles sampled

    Other: Blood culture sampling

Interventions

  • OtherBlood culture sampling

    Patients with blood culture sampling as standard of care. Two to four additional blood culture bottles sampled that will be spiked with known bacterial species to determine their electrochemical profiles

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What researchers measure

Primary outcomes

  1. List of samples with an electrochemical profile

    List of samples (bacterial strain and corresponding pseudonymized blood culture) for which an electrochemical profile of the growing bacteria within the blood culture bottle was successfully obtained

    Time frame: From enrollment until the end of measurment of an electrochemical fingerprint in the blood cultures from the patient spiked with bacterial strains, assessed within up to one week after blood culture sampling

Secondary outcomes

  1. Identification performance

    Identification performance of electrochemical profiling of the growing bacteria followed by machine learning analysis

    Time frame: End of the study (18 months)

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Study locations

1 of 2 sites recruiting
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References and documents

Publications

  • Lamy B, Sundqvist M, Idelevich EA; ESCMID Study Group for Bloodstream Infections, Endocarditis and Sepsis (ESGBIES). Bloodstream infections - Standard and progress in pathogen diagnostics. Clin Microbiol Infect. 2020 Feb;26(2):142-150. doi: 10.1016/j.cmi.2019.11.017. Epub 2019 Nov 22. PubMed 31760113 ↗
  • Dubourg G, Lamy B, Ruimy R. Rapid phenotypic methods to improve the diagnosis of bacterial bloodstream infections: meeting the challenge to reduce the time to result. Clin Microbiol Infect. 2018 Sep;24(9):935-943. doi: 10.1016/j.cmi.2018.03.031. Epub 2018 Mar 29. PubMed 29605563 ↗
  • T Babin, T Dedole, P Bouvet, PR Marcoux, M Gougis, P Mailley (2023) Electrochemical label-free pathogen identification for bloodstream infections diagnosis: towards a machine learning based smart blood culture bottle. Sensors and Actuators B. (open access) https://doi.org/10.1016/j.snb.2023.133748

Individual participant data

Plan to share: No

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Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Jul 2026 (actual). Primary completion is estimated for Jan 2028, 18 months after the start.

Of 34 non-industry interventional studies with no phase under Bacteremia, half reached primary completion within 34 months of starting (the median), counting those still running; a quarter within 13 and three quarters within 64. This study's planned 18 months is below that.

Counting every sponsor, half of 35 studies reached it within 34 months; a quarter within 13 and three quarters within 64.

How these figures are worked out, and which studies are left out of them.

Registered
Feb 11, 2025
First posted
Feb 28, 2025
StartActual
Jul 13, 2026
Primary completionEst.
Jan 2028
CompletionEst.
Jan 2028
Last update
Jul 22, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jul 22, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06853301
Collaborators
CEA - Leti
Responsible party
Sponsor
First posted
Feb 28, 2025
Start date
Jul 13, 2026
Primary completion
Jan 2028 (estimated)
Completion
Jan 2028 (estimated)
Last update
Jul 22, 2026

Study contacts

Yvan CASPAR, PharmD, PhD
Contact
YCaspar@chu-grenoble.fr
+33 476765479

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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