An observational study in Ephedrine, Norepinephrine and Postoperative Delirium (POD), sponsored by Riverside University Health System Medical Center. Not yet recruiting. Per ClinicalTrials.gov, last updated 2025-02-25.
Sponsored by Riverside University Health System Medical Center · Observational
This retrospective study aims to investigate the effects of norepinephrine compared to ephedrine, administered on the day of surgery, on the incidence of postoperative delirium.
This retrospective analysis will be conducted using data from the TriNetX US Collaborative Network. This study was designed to assess the impact of intraoperative norepinephrine versus intraoperative ephedrine use on postoperative delirium. Inclusion criteria includes patients who underwent surgery (CPT code 1003143) and were either administered ephedrine or norepinephrine on the day of surgery and did not receive both vasopressors on the day of surgery. Exclusion criteria exclude patients who underwent neurology and neuromuscular surgery, cardiac surgery, and cardiac procedures; patients who were administered epinephrine or dopamine on the day of surgery; patients who were administered ephedrine or norepinephrine at any time within the 7 days following the day of surgery to account for patients that might have required pressor infusions for other causes; or a prior history of disorientation (ICD-10 code R41.0) or unspecified dementia (F03).
Propensity score matching through TriNetX will be used to adjust for age, sex, race, BMI, and comorbidities including cerebrovascular disease (ICD-10 code I60-I69), chronic heart failure (I11.0), primary hypertension (I10, I11.9), chronic obstructive pulmonary disease (COPD) (J42, J43, J44, J47), asthma (J45), chronic kidney disease (CKD) (I12, I13), diabetes mellitus (E08-E13), depression (F32.A), schizoaffective disorders (F25), alcohol and drug abuse (F10.1, F10.2, Z71.4), smoking status (F17.2, F17.21), and history of antipsychotic (CN700) and benzodiazepine (C302) usage.
Independent t-tests and chi-squared tests will be used to compare postoperative delirium across the cohorts. To evaluate the relationship between norepinephrine and postoperative delirium versus ephedrine and postoperative delirium, risk differences, and risk ratios with 95% CIs will be calculated following propensity score matching. The TriNetX platform will be used for all analyses, with p \< 0.05 representing statistical significance.
1,057 studies on the registry are indexed under Delirium; 238 are open to participants now.
This study's planned enrollment of 10,000 is above the median of 200 across 418 observational studies indexed under Delirium.
Browse Delirium studies →Riverside University Health System Medical Center is the lead sponsor of 10 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients within the TriNetX database.
Ephedrine group:
Inclusion Criteria:
Exclusion Criteria:
Norepinephrine group:
Inclusion Criteria:
Exclusion Criteria:
This group received ephedrine on the day of surgery.
Drug: Ephedrine
This group received norepinephrine on the day of surgery.
Drug: Norepinephrine
Received ephedrine the same day of surgery.
Received norepinephrine the same day of surgery.
Postoperative delirium
The outcome of postoperative delirium will be observed using the ICD-10 codes F05, R40, and R41 for delirium, somnolence, and disorientation, respectively.
Time frame: Within 7 days following surgery.
No study locations are listed for this record.
Plan to share: No — We do not have an IPD in place at this time.
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.
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Riverside University Health System Medical Center