An observational study in Sarcopenia in Elderly, Cachexia; Cancer; Sarcopenia and Body Composition Changes, sponsored by Royal Marsden NHS Foundation Trust. Not yet recruiting at 1 site in United Kingdom. Open to participants aged 70 Years and older. Per ClinicalTrials.gov, last updated 2024-10-08.
Sponsored by Royal Marsden NHS Foundation Trust · Observational
The primary aim of the study is to explore body composition in older adults (aged 70 years and over) with cancer, undergoing systemic anticancer treatment. Additional aims include to explore the extent of body composition changes and whether changes are tumour specific, the incidence for cancer-related cachexia and sarcopenia and finally, how body composition can inform nutritional management of older adults with cancer.
To do this, the investigators applied for and were awarded funding from a company called Nutricia to pay for a band 4 (0.6 WTE for 7 months) to take monthly body composition measures on the patients who are eligible, accepting of assessment by the Senior Adult Oncology Programme (SAOP) and consent to these measures. Measurements will include an analysis from the Bioelectrical Impedance Analysis (BIA) machine which will quantify fat, lean muscle, and water content; waist to hip ratio; handgrip strength; calf circumferences. Socio-demographic data will also be collected.
Descriptive data analysis will take place to explore possible trends and associations which may inform future research and drive even further personalised care for this growing and typically underrepresented in research, population.
336 studies on the registry are indexed under Cachexia; 76 are open to participants now.
This study's planned enrollment of 30 is below the median of 141 across 90 observational studies indexed under Cachexia.
Browse Cachexia studies →Royal Marsden NHS Foundation Trust is the lead sponsor of 272 studies on the registry; 52 are open to participants now.
Counted across the registry records on this site, refreshed daily.
adults aged 70 years and older, with a cancer diagnosis who are to receive systemic anti-cancer treatment
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Adults eligible and accepting of assessment in the SAOP.
Exclusion Criteria:
Other: No Intervention: Observational Cohort
No intervention; observation cohort study
Explore body composition in older adults with cancer starting SACT.
means and standard deviations (or medians and interquartile ranges if not normally distributed) of body composition measures taken from all participants at baseline/ first Research Clinic, analysed at end of study will quantify this objective.
Time frame: 7 months
Explore the extent of body composition changes in older adults with cancer during SACT.
percentage change between body composition measures taken from all participants at baseline and during monthly Research Clinics, analysed at end of study will quantify this objective.
Time frame: 7 months
Explore whether there are differences between body composition in older adults with cancer receiving SACT, based on tumour diagnosis
Tumour types will be categorised with frequencies reported. Means calculated from Exploratory Endpoint #2 of each category will be compared at end of study and quantify this objective.
Time frame: 7 months
Explore how body composition can inform nutritional management of older adults with cancer receiving SACT.
nutritional interventions provided (if any) will be categorised and cross-examined for correlations with mean percentage change in body composition (Outcome #2) at end of study to quantify this objective.
Time frame: 7 months
Investigate the incidence for cancer-related cachexia and sarcopenia in older adults with cancer receiving SACT.
standardised cut off values (World Health Organization, 2011; Cruz-Jentoft et al., 2019; Roeland et al., 2020) for indicating the presence of cancer-related cachexia and sarcopenia will be extracted from body composition measures taken from all participants at baseline and during monthly Research Clinics and presented as an overall frequency (of participants) and frequencies within each tumour type. Analysis will occur at end of study and will quantify this objective.
Time frame: 7 months
This study is not yet recruiting, as verified in Oct 2024. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Royal Marsden NHS Foundation Trust →