An observational study in Gingivitis, Depression and Inflammation, sponsored by Medipol University. Completed at 1 site in Turkey. Open to participants aged 18 Years to 53 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-05-24.
Sponsored by Medipol University · Observational
The goal of this observational study is to evaluate the inflammatory saliva biomarkers in depression and gingivitis.
The main question will be ; Will there be an increase at salivary biomarkers with depression patients and is it associated with gingivitis?
Background: The neuroimmune regulation disorder in depression patients causes the progression of inflammatory periodontal disease. The present study was to evaluate the periodontal health status and the levels of Triggering receptor expressed on myeloid cells 1 (TREM-1), peptidoglycan recognition protein 1 (PGLYRP1) and interleukin-1 beta (IL-1β) in individuals diagnosed with depression and to compare these findings with those of systemically healthy individuals.
Methods: Forty-two depression patients were classified in two groups: depression with gingivitis (DG) and depression with periodontally healthy (DPH) patients. Additionally, 23 systemically and periodontally healthy (SPH) individuals were enrolled to the study. Periodontal parameters were recorded. Saliva samples were collected and salivary levels of TREM-1, PGLYRP1, IL-1β were measured using Enzyme-linked Immunosorbent Assay (ELISA) kits.
depression regardless of periodontal status.
590 studies on the registry are indexed under Gingivitis; 104 are open to participants now.
This study's enrollment of 65 is below the median of 90 across 104 observational studies indexed under Gingivitis.
Browse Gingivitis studies →Medipol University is the lead sponsor of 311 studies on the registry; 86 are open to participants now.
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This study was carried out on 65 participants in total, including 42 individuals who applied to Aydın State Hospital Psychiatry Outpatient Clinic, diagnosed with depressive disorder, were classified in 2 different groups; depression with gingivitis (DG), depression with periodontally healthy (DPH) patients and 23 systemically and periodontally healthy (SPH) individuals who applied to Adnan Menderes University Faculty of Dentistry.
Inclusion Criteria:
Exclusion Criteria: Patients with
The diagnosis of depressive disorder was established using the Structured Clinical Interviews for Axis I Disorders (SCID) criteria of the Diagnostic and Statistical Manual of Mental Disorders. the gingivitis group was determined by the criteria of pocket depth of 3 mm or less.
Other: Periodontal clinical measurements, Saliva sampling
The diagnosis of depressive disorder was established using the Structured Clinical Interviews for Axis I Disorders (SCID) criteria of the Diagnostic and Statistical Manual of Mental Disorders.
Other: Periodontal clinical measurements, Saliva sampling
This group contists of individuals who are systemically and periodontally healthy
Other: Periodontal clinical measurements, Saliva sampling
Clinical periodontal indices; Probing depth, Clinical attachment level, bleeding on probing, gingival index, and plaque
SalivaryTREM-1
Both, soluble and membrane-bound TREM-1, are detected by the TREM-1 ELISA.
Time frame: 06-09 2019
Salivary PGLYRP1
Both, soluble and membrane-bound PGLYRP1 are detected by the PGLYRP1 ELISA.
Time frame: 06-09 2019
Salivary IL-1β
Both, soluble and membrane-bound IL-1β detected by the IL-1β ELISA.
Time frame: 06-09 2019
Plan to share: Undecided
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This study is completed, as verified in May 2024. You cannot join it, but the record below documents what was studied.
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