An observational study in Inflammation, Cardiovascular Diseases and Myocarditis, sponsored by King's College London. Not yet recruiting. Open to participants aged 13 Years and older. Per ClinicalTrials.gov, last updated 2024-05-14.
Sponsored by King's College London · Observational
Following acute cardiovascular injury, inflammation is vital to activate reparative mechanisms. However, there is compelling evidence implicating excessive inflammation and dysregulated resolution in fibrosis, ventricular remodelling, and heart failure (HF). Recently, the anti-inflammatory agent colchicine reduced cardiovascular events after myocardial infarction (MI) compared to placebo, indicating that targeting inflammation in acute cardiovascular conditions is feasible. Several acute cardiovascular conditions are characterised by inflammation, including myocarditis, MI, and acute heart failure. However, there is large variability in definition, epidemiology, clinical presentation, pathophysiology, and natural history of acute inflammatory cardiovascular diseases. This relates, in part, to the difficulty in performing adequately powered studies. Clinical studies that include sufficient patients and extended observation periods are necessary to address some of these knowledge gaps. This registry aims to collate routinely collected clinical data on patients with acute cardiovascular diseases characterised by inflammation in an observational-based registry. By doing so, the investigators hope to understand the contribution of inflammation to the pathophysiology of acute cardiovascular disease, improve risk stratification, and identify potential novel therapeutic targets.
2,135 studies on the registry are indexed under Heart Diseases; 252 are open to participants now.
This study's planned enrollment of 1,000 is above the median of 350 across 592 observational studies indexed under Heart Diseases.
Browse Heart Diseases studies →King's College London is the lead sponsor of 520 studies on the registry; 126 are open to participants now.
Compared within Heart Diseases, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Inflammation. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Patients who are diagnosed with acute cardiovascular diseases can be included in the registry.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
This registry aims to collate routinely collected clinical data on patients with acute cardiovascular diseases.
Other: Observation
Observation
All-cause mortality
Primary outcome will include all-cause mortality, but will vary by specific research project conducted within the registry.
Time frame: 1 year
No study locations are listed for this record.
Plan to share: No — Partner sites (including those outside the UK) will store linkage files for their own patients in accordance with local policies. Data will be stored on a research database (REDCap) hosted by King's College London. Each participating centre will have linkage codes for their own patients only. Therefore, exported data will not be identifiable to other centres.
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in May 2024. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.