An interventional study of Re-infusion of unwashed shed blood in Coronary Artery Disease, Blood Transfusion Complication and Cardiovascular Complication, sponsored by Damascus University. Completed at 1 site in Syria. Open to participants aged 40 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-09-01.
Sponsored by Damascus University · Not applicable, Interventional, and Treatment
To assess the efficacy and side-effects of re-infusion of unwashed shed blood during off-pump coronary artery surgery using a novel cardiotomy circuit.
Introduction Blood transfusion is often required during cardiac surgical operations, and may be associated with known risks and complications. Off-pump coronary artery surgery has been shown to be associated with reduced need for blood transfusion, and cell-savers are widely used as an additional method for reducing blood transfusion demands.
Auto-transfusion of unwashed suctioned blood intra-operatively is thought to increase the inflammatory response and infective complications, but data related to this approach are scares.
Aims
To assess the effects and benefits of using an isolated cardiotomy circuit for re-infusion of unwashed shed blood during off-pump surgery and compare it to the conventional no re-infusion technique. Assessments will focus on:
Study design A prospective study involving patients undergoing off-pump coronary artery bypass surgery. Patients will be randomized to two groups; an isolated cardiotomy circuit for re-infusion of unwashed shed blood will be used in group (a) and the conventional no re-infusion technique will be used in group (b).
Participants Patients undergoing off-pump coronary artery bypass surgery.
Setting Damascus University Cardiac Surgery Hospital
4,857 studies on the registry are indexed under Coronary Artery Disease; 890 are open to participants now.
This study's enrollment of 50 is below the median of 124 across 3,006 interventional studies indexed under Coronary Artery Disease.
Browse Coronary Artery Disease studies →Damascus University is the lead sponsor of 212 studies on the registry; 11 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A “mini-stroke”: temporary stroke-like symptoms caused by reduced blood flow to part of the brain, spinal cord or eye, without signs of a new stroke on a scan.
Stroke symptoms need emergency care at once, even if they go away.
TIA (transient ischaemic attack)
A “mini-stroke”: temporary stroke-like symptoms caused by reduced blood flow to part of the brain, spinal cord or eye, without signs of a new stroke on a scan.
Stroke symptoms need emergency care at once, even if they go away.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Re-infusion of unwashed shed blood
Procedure: Re-infusion of unwashed shed blood
No re-infusion of unwashed shed blood
Use of an isolated cardiotomy circuit for re-infusion of unwashed shed blood during off-pump coronary artery surgery
blood transfusion requirements
volume of blood (ml) transfused
Time frame: up to 5 days post-operatively
inflammatory response
changes in IL-6
Time frame: pre-operatively, immediately post-operatively, and 24 hours post-operatively
alveolar/arterial oxygen pressure gradients
changes in alveolar/arterial oxygen pressure gradients peri-operatively
Time frame: pre-, 4 hours post-operatively, and post-extubation
cost-benefit
cost of blood products, circuits and hospital stay
Time frame: up to 5 days postoperatively
Neuro-markers
Changes in S-100
Time frame: pre-operatively, immediately post-operatively, and 24 hours post-operatively
myocardial marker CK-MB
changes in CK-MB
Time frame: pre-operatively, immediately post-operatively, and 24 hours post-operatively
myocardial marker troponin-I
changes in troponin-I
Time frame: pre-operatively, immediately post-operatively, and 24 hours post-operatively
blood loss
volume (ml) of blood lost
Time frame: up to 24 hours post-operatively
complement response
changes in C3a
Time frame: pre-operatively, immediately post-operatively, and 24 hours post-operatively
Plan to share: Yes — Data will be deposited in a Data Repository
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report, Analytic code
Time frame: Upon completion of the study and will be there permanently
Access criteria: Open to all
Ran from Mar 2024 to primary completion in Mar 2026, 24 months.
Of 753 non-industry interventional studies with no phase under Coronary Artery Disease, half reached primary completion within 33 months of starting (the median), counting those still running; a quarter within 15 and three quarters within 53. This study's 24 months is below that.
Counting every sponsor, half of 930 studies reached it within 30 months; a quarter within 15 and three quarters within 50.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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