An observational study in Acute Respiratory Distress Syndrome, sponsored by Hospices Civils de Lyon. Recruiting at 4 sites in France. Open to participants aged 15 Years and older. Per ClinicalTrials.gov, last updated 2024-01-31.
Sponsored by Hospices Civils de Lyon · Observational
Acute respiratory distress syndrome remains a deadly disease with hospital mortality remaining between 40 to 50%. ARDS mortality risk factors have been identified from patient history, common clinical and biological variables in the lung SAFE study. Part of ARDS mortality is attributable to ventilator-induced lung injury (VILI), in relation with inappropriate settings on the ventilator. Tidal hyperinflation and recruitment/derecruitment during lung inflation are 2 identified mechanisms leading to VILI, that may be identified on computed tomography while poorly identified with variables collected at the bedside.
The aim of this study is to identify whether tidal hyperinflation identified on computed tomography is a risk factor for ARDS mortality, independently from know bio-clinical risk factors.
1,597 studies on the registry are indexed under Respiratory Distress Syndrome; 312 are open to participants now.
This study's planned enrollment of 210 is above the median of 100 across 540 observational studies indexed under Respiratory Distress Syndrome.
Browse Respiratory Distress Syndrome studies →Hospices Civils de Lyon is the lead sponsor of 1,826 studies on the registry; 439 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients will be screened from the population of patient hospitalized for ARDS in the participating centers
Exclusion Criteria:
As the study aim to identify whether tidal hyperinflation is an independent predictor for ARDS mortality, and as this variable will be entered as a quantitative predictor in the multivariate model, the study encompass a single group of patient (i.e. all included patients)
Radiation: Low dose computed tomography to evaluate biomechanical parameters in the lung
In the participating to the study, response to PEEP increase and tidal inflation are evaluated with a software computing biomechanical parameters (tidal hyperinflation and lung recruitability). Tidal hyperinflation and recruitment are computed on CT images acquired within 72 hours after ARDS onset or with 72h after ECMO onset.
Odd ratio of tidal hyperinflation assessed on CT at day-0 as an independent predictor of 90-day mortality
Tidal hyperinflation is computed as the volume difference of hyperinflated lung (i.e., with CT attenuation between -1000 and -900 Hounsfield units) between and-expiration and end-inspiration at the PEEP level chosen by clinician
Time frame: Day-0 (time of realization of CT scan)
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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Respiratory Distress Syndrome→
Hospices Civils de Lyon