An observational study in Inflammatory Bowel Diseases, sponsored by Hepatopancreatobiliary Surgery Institute of Gansu Province. Completed at 4 sites in China. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2024-11-19.
Sponsored by Hepatopancreatobiliary Surgery Institute of Gansu Province · Observational
The purpose of this study was to evaluate the association between gallstone disease and the risk of inflammatory bowel disease.
Crohn's disease and ulcerative colitis , collectively known as inflammatory bowel diseases , have increased substantially over the past few decades affecting nearly 6.8 million individuals worldwide. The etiology of IBD remains obscure, possibly involving a complex interaction between the genetic, environmental or microbial factors and the immune responses. Gallstone disease is one of the most common and costly gastroenterological disorders, with a prevalence of 10-20% in Europe and America. Considering that gallstones and IBD also share specific risk factors, such as obesity, inappropriate diet and metabolic hormone levels, and have the pathophysiologic linkage, such as changes in gut microbiota composition and bile acid profile, the investigators propose that the occurrence of gallstones may predict the subsequence risk of IBD. However, investigations concerning the association is lacking.
963 studies on the registry are indexed under Intestinal Diseases; 174 are open to participants now.
This study's enrollment of 5,035 is above the median of 140 across 377 observational studies indexed under Intestinal Diseases.
Browse Intestinal Diseases studies →Hepatopancreatobiliary Surgery Institute of Gansu Province is the lead sponsor of 41 studies on the registry; 8 are open to participants now.
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IBD patients
Exclusion Criteria:
IBD patients (including Crohn's disease and Ulcerative colitis)
Other: gallstones
Age, sex, and calendar-year matched controls sampled from non-IBD patients to be a round number of at least four times the number of cases
Other: gallstones
fellow up if the patients have gallstones
The prevalence of gallstone disease among patients with or without IBD
We assess the prevalence as the number of gallstone diseases divided by the number of IBD patients or non-IBD patients. Gallstone disease was diagnosed as presence of gallstones, cholecystectomy, choledocholithotomy and Endoscopic Retrograde Cholangio-Pancreatography (ERCP).
Time frame: 10 years
The odds ratio of the association between the presence of gallstone disease and risk of inflammatory bowel disease
The odds ratio is a ratio of two sets of odds: the odds in case group (gallstone diseases with IBD divided by non-gallstone disease with IBD) versus the odds in control group (gallstone diseases without IBD divided by non-gallstone disease without IBD). Finally, we can calculate the odds ratio by dividing the ratio of the case group by the ratio of the control group.
Time frame: 10 years
Plan to share: Undecided — After completed
This study is completed, as verified in Nov 2024. You cannot join it, but the record below documents what was studied.
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Hepatopancreatobiliary Surgery Institute of Gansu Province