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RecruitingNCT05851248Updated Feb 19, 2026

Free Mucogingival Graft for Isolated Root Coverage

An interventional study of Buccal muco-gingival tissue graft and Palatal connective tissue graft in Free Mucogingival Grafts, Gingival Recession and Root Coverage, sponsored by Universidad de Murcia. Recruiting at 1 site in Spain. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-19.

Sponsored by Universidad de Murcia · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 3 months after the study started (first participant enrolled Jan 2023, registered Apr 2023).
  • Started Jan 2023; still recruiting 3 years 9 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
24
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

The goal of this clinical trial is to to describe and evaluate an approach, free mucogingival graft (FMG), in periodontal plastic surgery for root coverage (RC) in lower incisor gingival recessions (GR) with mucogingival conditions and deformities (MCD) that might negatively influence the outcomes of conventional RC procedures.

02

Conditions studied

  • Free Mucogingival Grafts
  • Gingival Recession
  • Root Coverage
  • Periodontal Plastic Surgery

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03

In context

Gingival Recession

402 studies on the registry are indexed under Gingival Recession; 98 are open to participants now.

This study's planned enrollment of 24 is below the median of 30 across 368 interventional studies indexed under Gingival Recession.

Browse Gingival Recession studies →

Lead sponsor

Universidad de Murcia is the lead sponsor of 78 studies on the registry; 16 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Healthy patients with deep GR associated with lower incisor MCD.
  • Full mouth plaque and bleeding scores were \<20%.

Exclusion criteria

Exclusion Criteria:

Patient characteristics:

  • Smoking ≥10 cigarettes a day.
  • Medications or systemic contraindications for oral surgery.
  • Pregnancy.

Defects:

  • Thin scalloped biotype (AND/OR)
  • Underlying bone dehiscence (AND /OR)
  • Generalized GR affecting most sextants.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
24 participants (estimated)

Study arms

  • Experimental
    Buccal muco-gingival tissue graft

    Procedure: Buccal muco-gingival tissue graft

  • Active comparator
    Palatal connective tissue graft

    Procedure: Palatal connective tissue graft

Interventions

  • ProcedureBuccal muco-gingival tissue graft

    Recipient Site Preparation. In the GR, a sulcular incision limited to the vestibular face will be made, which will continue until reaching the tip of the buccal papillae on each side of the GR. Two vertical incisions from the base of the two papillae to the bottom of the vestibule and one horizontal incision will connect the ends of both vertical incisions to remove the pedicle tissue. The exposed root surface will be cleaned and smoothed with mini-curettes. Donor site preparation. The incisions will be made in the same way as in the recipient area, including both papillae. The vertical incision will measure the distance from the cementoenamel junction (CEJ) to the bony dehiscence in the GR tooth, plus at least 2 mm. The tissue between the incisions will be elevated fjull or partial thickness close to the bone in the keratinized portion and superficially in the mucosal portion. A soft tissue substitute will be adapted and sutured to protect the donor site.

  • ProcedurePalatal connective tissue graft

    Recipient Site Preparation. In the GR, a sulcular incision limited to the vestibular face will be made, which will continue until reaching the tip of the buccal papillae on each side of the GR. Two vertical incisions from the base of the two papillae to the bottom of the vestibule and one horizontal incision will connect the ends of both vertical incisions to remove the pedicle tissue. The exposed root surface will be cleaned and smoothed with mini-curettes. Donor site preparation A connective tissue graft will be taken from the palatal area, at the level of the premolars, which will include the two papillae. The size of the graft will be the same as that of the recipient area. A soft tissue substitute will be adapted and sutured to protect the donor site, especially if there is exposed bone.

06

What researchers measure

Primary outcomes

  1. buccal Recession (bREC)

    Buccal recession measurement, will be assessed with a periodontal probe, measured in mmm on the buccal aspect, from the CEJ to the gingival margin zenith.

    Time frame: 12 months

Secondary outcomes

  1. buccal Clinical Attachment Level (bCAL)

    bCAL will be assessed with a periodontal probe, measured in mm from the CEJ to the bottom of the pocket, on the buccal aspect.

    Time frame: 12 months

  2. interproximal Clinical Attachment Level (iCAL)

    iCAL will be assessed with a periodontal probe, measured in mm from the CEJ to the bottom of the pocket, on the interproximal aspect.

    Time frame: 12 months

  3. Interproximal papilla tip location (PT)

    Taking as reference the level of the mid-axis of the tooth, PT will be measured the distance from the CEJ at the zenith of the tooth to the tip of the papilla. A positive value will be recorded when the tip of the papillae is located coronally to the CEJ and a negative value otherwise. This outcome will be assessed with a periodontal probe and measured in mmm.

    Time frame: 12 months

  4. keratinized tissue width (KT)

    KT will be assessed with a periodontal probe, measured in mm on the buccal aspect, from the gingival margin to the mucogingival line.

    Time frame: 12 months

  5. vestibule depth (VD)

    VD will be measured, from the mucosal margin to the point of greatest concavity of the mucobuccal fold. The measure will be assessed with a periodontal probe in mm.

    Time frame: 12 months

  6. Soft tissue attached to alveolar bone (STAB)

    STAB will be measured from the gingival margen to the perpendicular mucosal insertion. The measure will be assessed with a periodontal probe in mm.

    Time frame: 12 months

Other outcomes

  1. Root Coverage (RC percentage)

    RC percentage will be calculated by the following formula: \[(basaline recession depth - 12 months recession depth) / basaline recession depth\] x100. The measure will be assessed with a periodontal probe in mm.

    Time frame: 12 months

  2. Complete root coverage (CRC)

    It will assessed if the gingival margen is at or above the CEJ. The measure will be assessed with a periodontal probe in mm.

    Time frame: 12 months

07

Study locations

1 of 1 sites recruiting
  • Centro Odontologico Del Sureste Slp
    Murcia, Murcia 30007, Spain
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 19, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT05851248
Lead sponsor
Universidad de Murcia
Responsible party
Antonio José Ortiz Ruiz, MD (Professor and Researcher, Universidad de Murcia) — Principal investigator
First posted
May 9, 2023
Start date
Jan 2, 2023
Primary completion
Dec 22, 2026 (estimated)
Completion
Apr 22, 2027 (estimated)
Last update
Feb 19, 2026

Study contacts

Antonio J Ortiz-Ruiz, MD
Contact
ajortiz@um.es
+34 868888581
José A Moreno-Rodríguez, DDS
Contact
joseantonio171087@hotmail.com
+34 620538483

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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