An interventional study of Gum Graft Placed on Denuded Bone and Gum Graft Placed on Split Thickness Periosteal Bed Preparation in Gingival Recession, sponsored by University of Iowa. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years to 95 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-09.
Sponsored by University of Iowa · Not applicable, Interventional, and Treatment
Among 45 studies in Gingival Recession with a site in United States — 12 open to participants now, 16 under way, 1 of them phase 3. Gingival Recession · United States.
Among the 45 studies in Gingival Recession with a site in United States, this one is the 8th largest by planned enrollment of the 41 interventional ones, is the only one that started in 2028, is one of 32 with no phase, reaches primary completion later than 14 of the 15 other live ones, and was the 31st registered.
426 studies on the registry are indexed under Gingival Recession; 106 are open to participants now.
This study's planned enrollment of 50 is above the median of 30 across 390 interventional studies indexed under Gingival Recession.
Browse Gingival Recession studies →12 of the 45 studies in Gingival Recession with a site in United States are open now, in 1 country. Each count lists the studies.
Of the 64 Gingival Recession studies recruiting now, 30 (47%) set no upper age limit and 31 (48%) stop at 75 or younger; 1 take children under 18; 36 take healthy volunteers.
This study: 18 Years to 95 Years · all sexes · healthy volunteers too.
The full table on the hub →45 studies; the count open now beside each. This study's row is marked.
First in 2005; this study’s year is marked. 1 started in 2028.
Median enrollment 24 across the 41 interventional studies, 24 across the 4 observational. Of the 25 that completed or were terminated, 7 (28%) have results posted.
6 of 45 have an industry lead sponsor. The 10 most frequent:
University of Iowa is the lead sponsor of 279 studies on the registry; 33 are open to participants now.
Of its 45 completed or terminated interventional studies of FDA-regulated products, 40 (89%) have results posted.
University of Iowa has 1 study filed under Gingival Recession — fewer than ten, so there is no comparison to draw.
6 of the studies in Gingival Recession with a site in United States that are under way reach primary completion within a year, 1 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07849270Phase 3Indiana UniversityNew In Situ Model Design for Caries and Erosion | 2027-01-29 |
| NCT04920136University of Alabama at BirminghamGain of Keratinized Mucosa Around Teeth and Dental Implants Using a Combination of Strip Gingival Graft and Acellular Dermal Matrix | 2026-12-30 |
| NCT06892496Virginia Commonwealth UniversityPatient-reported Outcomes of Donor Site Healing Using Different Palatal Protection Techniques | 2027-01 |
| NCT06037161Case Western Reserve UniversityComparison of Two Methods of Covering a Single Lower Front Tooth With Receded Gums | 2027-01-30 |
| NCT07386457Ohio State UniversityTaking Measurements of a Gum Graft Site as it Heals | 2027-05 |
Among the 45 studies in Gingival Recession with a site in United States, from their registry updates:
The goal of this clinical trial is to evaluate the dimensional changes in the short and long-term in patients with thin gum tissues who have gum grafts placed on either denuded bone or gum grafts placed on a bone with some tissues remaining.
The main question this study aims to answer is:
- Does the placement of free-epithelized gingival grafts (gum grafts) on full thickness bed preparation (having all of the tissue removed from the bone) lead to similar clinical, digital, and patient-related outcomes and measurements over a period of 12 months versus split thickness bed preparation (where a small layer of tissue is left over the bone) in patients with thin gum tissue phenotypes (gum tissue is generally less than 1.5 millimeters) who are in need of soft tissue augmentation procedures?
Participants will be asked to attend 8 visits, which include: (i) screening visit, (ii) prophylaxis visit, (iii) random assignment to Group A or Group B along with surgery and digital data collection, (iv) 2-week post-operative visit, (v) 6-week post-operative visit, (vi) 3-month follow-up visit, (vii) 6-month follow-up visit, (viii) 12-month follow-up visit. Also, Group A will have a free epithelialized gingival/mucosal graft (gum graft) placed on full thickness periosteal bed preparation where all of the tissue was removed (test group). Group B will have a free epithelialized gingival/mucosal graft (gum graft) on split thickness periosteal bed preparation where only a portion of the tissue was removed (control group). Researchers will compare Group A and Group B to see if there is a difference in clinical, digital, and patient-related outcomes and measurements over a period of 12 months.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
HbA1c
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Subjects in this arm will have a free epithelialized gingival/mucosal graft (gum graft) placed on full thickness periosteal bed preparation where all of the tissue was removed (test group).
Procedure: Gum Graft Placed on Denuded Bone
Group B will have a free epithelialized gingival/mucosal graft (gum graft) on split thickness periosteal bed preparation where only a portion of the tissue was removed (control group).
Procedure: Gum Graft Placed on Split Thickness Periosteal Bed Preparation
The provider will administer local anesthesia into the subject's gum in order to numb both the subject's donor and recipient areas for gum grafts. Next, the provider will use a surgical blade to dissect the gum graft from the subject's donor site. At the subject's recipient gum recession defect site, the provider will remove all of the subject's tissue, so that the bone is fully exposed before placing a gum graft from the donor site. Afterward, the provider will place sutures in the subject's recipient site in order to promote healing/re-growth.
The provider will administer local anesthesia into the subject's gum in order to numb both the subject's donor and recipient areas for gum grafts. Next, the provider will use a surgical blade to dissect the gum graft from the subject's donor site. At the subject's recipient gum recession defect site, the provider will dissect some of the tissue at the subject's recipient site but still keep a small layer of tissue at the subject's recipient site before placing a gum graft from the donor site. Afterward, the provider will place sutures in the subject's recipient site in order to promote healing/re-growth.
Change from Baseline in Gingival Thickness as assessed by measurement.
Tissue changes will be assessed in millimeters and percentage.
Time frame: Multiple time points (i.e., Baseline, 3 months, 6 months, 12 months)
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Aug 2028; primary completion for Jul 2030, 23 months later.
Of 233 non-industry interventional studies with no phase under Gingival Recession, half reached primary completion within 19 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 30. This study's planned 23 months is above that.
Counting every sponsor, half of 235 studies reached it within 19 months; a quarter within 11 and three quarters within 30.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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