An observational study in Prenatal Diagnosis and Closed-loop Management System of Congenital Talipes Equinovarus, sponsored by The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School. Recruiting at 1 site in China. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2022-12-06.
Sponsored by The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Observational
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The study intends to establish a closed-loop management from prenatal to postnatal through prospective cohort, and comprehensively utilize ultrasound and MRI technology to establish a prenatal diagnosis and evaluation system for congenital talipes equinovarus. On the basis of existing genetic testing, further use of whole-exome sequencing and other genomic methods to explore possible pathogenic genes and loci, and clarify the pathogenic mechanism of congenital talipes equinovarus. Therefore, congenital talipes equinovarus can improve its diagnosis and treatment capacity, reduce the disability rate related to congenital talipes equinovarus, and prevent it well.
69 studies on the registry are indexed under Clubfoot; 15 are open to participants now.
This study's planned enrollment of 100 is above the median of 55 across 27 observational studies indexed under Clubfoot.
Browse Clubfoot studies →The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School is the lead sponsor of 250 studies on the registry; 147 are open to participants now.
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Single pregnant women with "congenital talipes equinovarus" suggested by ultrasound in our hospital; Voluntary prenatal diagnosis; Those who voluntarily participate in this subject and can comply with the requirements of doctors; Voluntary interview with interviewees:
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1）Single pregnant women 2) "congenital talipes equinovarus" suggested by ultrasound
Exclusion Criteria:
Twin or multiple pregnancies
Genetic testing results of congenital talipes equinovarus
chromosomal microarray analysis or whole exome screening to find genetic abnormalities of congenital talipes equinovarus
Time frame: 2 years
Started Aug 2022 (actual). Primary completion is estimated for Aug 2024, 24 months after the start.
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The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School →