An Early Phase 1 interventional study of Diclofenac Sodium in Necrotic Pulp and Apical Periodontitis, sponsored by Cairo University. Status unknown. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-11-10.
Sponsored by Cairo University · Early Phase 1, Interventional, and Treatment
the aim of this study is to compare the effect of using Diclofenac Sodium Versus Calcium Hydroxide as Intracanal medication on intensity of postoperative pain, bacterial load reduction after root canal preparation and periapical matrix metalloproteinase 9 level (MMP-9) post-instrumentation and pre-obturation in teeth with necrotic pulp
To compare the effect of diclofenac sodium versus calcium hydroxide as intra canal medication on:
Secondary Outcome 1 Bacterial load reduction will be determined by bacterial counting using agar culture technique after root canal preparation (CFU/ml).
Secondary Outcome 2 Periapical MMP-9 level will be determined post-instrumentation and pre-obturation by ELISA.
1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.
This study's planned enrollment of 30 is below the median of 45 across 1,191 interventional studies indexed under Periodontitis.
Browse Periodontitis studies →Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.
Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria:
-
Inclusion criteria:
Mandibular single rooted permanent premolar teeth:
Exclusion Criteria:
calcium hydroxide will be placed as intracanal medication between visits.
Drug: Diclofenac Sodium
diclofenac sodium will be placed as intracanal medication between visits
Drug: Diclofenac Sodium
intracanal medication
change in Intensity of postoperative pain
measured using numerical rating scale (NRS) at 6, 12, 24 and 48- hours post-instrumentation and at 6, 12, 24 and 48 hours post-obturation.
Time frame: 6,12.24.48 hours
Bacterial load reduction
bacterial counting using agar culture technique after root canal preparation (CFU/ml).
Time frame: 7 days
Periapical MMP-9 level
determined post-instrumentation and pre-obturation by ELISA.
Time frame: 7 days
No study locations are listed for this record.
Plan to share: Undecided
No publications or documents are linked to this record.
This study is status unknown, as verified in Nov 2022. You cannot join it, but the record below documents what was studied.
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Cairo University