An interventional study of Burst and Ramp in Heart Disease, Implantable Cardioverter Defibrillator (ICD) and Heart Rhythm Disorders, sponsored by Rigshospitalet, Denmark. Recruiting at 1 site in Denmark. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-04.
Sponsored by Rigshospitalet, Denmark · Not applicable, Interventional, and Treatment
This is a pragmatic, two-group, cluster randomized trial designed to compare strategies for the Anti Tachycardia Pacing (ATP)-setting in the ventricular tachyarrhythmias (VT) zone when implanting a new implantable cardioverter defibrillator (ICD) in patients with heart disease in hospitals in Denmark.
The strategies are: "Burst" or "Ramp" after 1. ATP (which is always burst) in VT zone. VT zone is defined between 180-249 (up to 269 in special cases) heartbeats per minute.
The ICD will give either:
Burst: The ICD is programmed to give ATP with 4 bursts. Or Ramp: The ICD is programmed to give ATP with 1 burst and 3 ramps.
The participating hospitals will be assigned to one of two intervention strategies for periods of 4-months. The given intervention will follow the patient/ICD throughout the life time of the ICD, but with the possibility to reprogram at any time (intention to treat).
It is calculated that the study needs a total of 398 events (second to fourth ATP), which is estimated to require 3980 implanted ICDs. The participants will be followed until the end of the ICD life, which is estimated to be around 10 years.
451 studies on the registry are indexed under Tachycardia, Ventricular; 120 are open to participants now.
This study's planned enrollment of 3,980 is above the median of 71 across 280 interventional studies indexed under Tachycardia, Ventricular.
Browse Tachycardia, Ventricular studies →Rigshospitalet, Denmark is the lead sponsor of 1,007 studies on the registry; 175 are open to participants now.
Compared within Tachycardia, Ventricular, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Heart Diseases. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
- ICD implantation for primary or secondary prophylactic indication
Exclusion Criteria:
Other: Burst
Other: Ramp
ATP with 4 burst
ATP with 1 Burst + 3 Ramp
Arrhythmia cessation
The ability of the given ATP protocol to stop the ventricular arrhythmia
Time frame: The lifetime of the ICD, estimated 10 years
Defibrillation
Arrhythmia accelerates resulting in defibrillation/shock therapy
Time frame: The lifetime of the ICD, estimated 10 years
Plan to share: No — The data are considered sensitive personal data.
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