An Early Phase 1 interventional study of Placebo and Propranolol in Aging, Menopause and Hypoxia, sponsored by University of Missouri-Columbia. Recruiting at 1 site in United States. Open to female participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-10.
Sponsored by University of Missouri-Columbia · Early Phase 1, Interventional, and Basic science
The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.
1,076 studies on the registry are indexed under Hypoxia; 213 are open to participants now.
This study's planned enrollment of 75 is above the median of 45 across 769 interventional studies indexed under Hypoxia.
Browse Hypoxia studies →University of Missouri-Columbia is the lead sponsor of 365 studies on the registry; 69 are open to participants now.
Of its 43 completed or terminated interventional studies of FDA-regulated products, 29 (67%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Periods have stopped for good: usually no period for 12 months in a row without another medical reason, sometimes confirmed by a blood test (FSH).
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Postmenopausal
Periods have stopped for good: usually no period for 12 months in a row without another medical reason, sometimes confirmed by a blood test (FSH).
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will be exposed to hypoxia (low oxygen air) using a mask.
Drug: Placebo · Drug: Propranolol · Drug: Gemtesa
Participants will be exposed to the cold pressor test (ice water on the foot).
Drug: Placebo · Drug: Propranolol · Drug: Gemtesa
Participants will be exposed to hypercapnia (high carbon dioxide air) using a mask.
Drug: Placebo · Drug: Propranolol · Drug: Gemtesa
Participants will receive a placebo in pill form.
Participants will receive oral propranolol (1 mg/kg).
Participants will receive oral gemtesa (75 mg).
Forearm blood flow
Blood flow in the forearm measured with venous occlusion plethysmography.
Time frame: Change from baseline to 5 minutes.
Plan to share: No
No publications or documents are linked to this record.
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Studies of the drugs tested here: Propranolol · Vibegron
University of Missouri-Columbia →