An interventional study of GCF obtaining and Saliva Obtaining in Mouth Diseases, Periodontal Inflammation and Periodontal Diseases, sponsored by Akdeniz University. Completed at 1 site in Turkey. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-07-01.
Sponsored by Akdeniz University · Not applicable, Interventional, and Diagnostic
The aim of this study is; detection of interleukin(IL)-38, IL-36 gamma(γ) , IL-17 and matrix metalloproteinase(MMP)-9 levels in gingival crevicular fluid (GCF), saliva and serum samples of periodontally healthy, gingivitis and periodontitis patients and the possible correlation between these values and clinical parameters of periodontal diseases. Materials and methods: Samples were obtained from 90 systemically healthy non-smoker individuals with periodontitis (P, n=30), gingivitis(G, n=30) and healthy periodontium (S, n=30). Full-mouth clinical periodontal measurements including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), gingival index (GI) and plaque index (PI) were also recorded. Enzyme-linked immunosorbent assay (ELISA) was used to determine IL-38, IL-36γ, IL-17 and MMP-9 levels in the biological samples.
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This study's enrollment of 90 is above the median of 45 across 530 interventional studies indexed under Periodontal Diseases.
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Exclusion Criteria:
Full-mouth clinical periodontal measurements recorded and GCF, saliva serum obtained.
Diagnostic Test: GCF obtaining · Diagnostic Test: Saliva Obtaining · Diagnostic Test: Serum obtaining
Full-mouth clinical periodontal measurements recorded and GCF, saliva serum obtained.
Diagnostic Test: GCF obtaining · Diagnostic Test: Saliva Obtaining · Diagnostic Test: Serum obtaining
Full-mouth clinical periodontal measurements recorded and GCF, saliva serum obtained.
Diagnostic Test: GCF obtaining · Diagnostic Test: Saliva Obtaining · Diagnostic Test: Serum obtaining
Full-mouth clinical periodontal measurements recorded and GCF, saliva serum obtained.
Diagnostic Test: GCF obtaining · Diagnostic Test: Saliva Obtaining · Diagnostic Test: Serum obtaining
Full-mouth clinical periodontal measurements recorded and GCF, saliva serum obtained.
Diagnostic Test: GCF obtaining · Diagnostic Test: Saliva Obtaining · Diagnostic Test: Serum obtaining
GCF obtaining: 2 GCF samples, 1 from the interproximal surface of 2 different teeth that bleeding on probing(-), were taken from each participant
Saliva obtaining: 1,5 ml unstimulated whole saliva collected from each participant
Serum obtaining : 8 ml of venous blood was collected from each participant and collecting blood centrifuged to obtain serum
Levels of Interleukin-38 (pg/ml) in GCF, saliva and serum fluid
Time frame: 24 hours after taking the clinical measurements at the first visit
Levels of Interleukin-36 gamma (pg/ml) in GCF, saliva and serum fluid
Time frame: 24 hours after taking the clinical measurements at the first visit
Levels of Interleukin-17 (pg/ml) in GCF, saliva and serum fluid
Time frame: 24 hours after taking the clinical measurements at the first visit
Levels of Matrix Metalloproteinase-9 (ng/ml) in GCF, saliva and serum fluid
Time frame: 24 hours after taking the clinical measurements at the first visit
Plan to share: Yes
Supporting information: Study protocol, Sap, Icf
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This study is completed, as verified in Jun 2022. You cannot join it, but the record below documents what was studied.
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Akdeniz University