An observational study in Glaucoma, Glaucoma, Angle-Closure and Macular Pigment Optical Density, sponsored by Zhongshan Ophthalmic Center, Sun Yat-sen University. Status unknown at 1 site in China. Open to participants aged 40 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-02-13.
Sponsored by Zhongshan Ophthalmic Center, Sun Yat-sen University · Observational
Glaucoma is the leading cause of irreversible blindness in the world, and primary angle-closure glaucoma (PACG) is the most important type of glaucoma in Asia. Primary angle closure disease (PACD) is a group of diseases related to PACG, and the pathogenesis is still unclear. Macular pigment has the functions of filtering short-wavelength waves and anti-oxidation, which are related to visual function. Previous studies have found that the macular pigment density (MPOD) is significantly reduced in primary open-angle glaucoma. This project uses the single-wavelength reflection method to measure MPOD, observes the characteristics of PACD and the normal control group's changes in retinal MPOD, and explains the relationship between PACD's MPOD changes and angle-closure glaucoma optic nerve damage
Observation index： Visual acuity，Intraocular pressure，Ophthalmoscope，MPOD，Visual field and OCT.
Inspection parameters of OCT：
91 studies on the registry are indexed under Glaucoma, Angle-Closure; 17 are open to participants now.
This study's planned enrollment of 60 is below the median of 225 across 32 observational studies indexed under Glaucoma, Angle-Closure.
Browse Glaucoma, Angle-Closure studies →Zhongshan Ophthalmic Center, Sun Yat-sen University is the lead sponsor of 164 studies on the registry; 80 are open to participants now.
Compared within Glaucoma, Angle-Closure, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Glaucoma. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Outpatients >=40 years old PACD
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Over 40 years old, regardless of gender. Patients diagnosed with PACD (PACG or PAC or PACS) with phakic eyes. Peripheral iridectomy or trabeculectomy, more than 3 months after operation.
Other: Ocular examination
Healthy population matched by sex and age.
Other: Ocular examination
All participants underwent a detailed examination, including visual acuity, slit lamp biomicroscopy, direct ophthalmoscopy, optometry noncontact tonometry,MPOD measurement and optical coherence tomography (OCT) measurement
Macular Pigment Optical Density（MPOD）Measurement
A one-wavelength fundus reflectance method (Visucam 200; Carl Zeiss Meditec) was used for the detection of MPOD as previously described. The right or left eye was randomly selected for measurement. The parameters and profiles of MPOD in a 7-degree eccentricity that corresponded to a 4 mm diameter were evaluated and output. Parameters included max and mean optical density (OD), volume, and area. MaxOD and MeanOD with units "d.u." (initial of density units) were used for the analyses.
Time frame: 3 months after surgery
Retinal nerve fiber layer thickness
Detection by optical coherence tomography (OCT). Circumpapillary RNFL scans were obtained using the standard 3.4 mm 12-degree circumpapillary nerve fiber layer scan protocol.We recorded superior, inferior, nasal, temporal, and total RNFL thickness.
Time frame: 3 months after surgery
Ganglion cell complex (GCC)thickness
Detection by optical coherence tomography (OCT). The distance from the internal limiting membrane and outer edge of the outer plexiform layer was defined as GCC thickness.
Time frame: 3 months after surgery
Mean central retina thickness
Detection by optical coherence tomography (OCT). CRT thickness was defined as distance between the internal limiting membrane and the inner edge of the retinal pigment epithelium.
Time frame: 3 months after surgery
Mean outer retinal thickness
Outer retinal (OR) thickness was calculated by subtracting GCC thickness from CRT.
Time frame: 3 months after surgery
Visual Field Test
The visual field test uses the 30-2 Threshold Test on the Humphrey Visual Field Analyzer.According to the mean deviation (MD) values generated by the software, three groups of disease severity were classified: the mild group with MD \> -6 dB, the moderate group with MD between -6 and -12 dB, and the severe group with MD \< -12 dB
Time frame: 3 months after surgery
Visual acuity
Use Snellen visual acuity chart to measure naked eye vision and best corrected vision
Time frame: 3 months after surgery
Intraocular pressure
Using non-contact tonometer (NCT) measuring intraocular pressure
Time frame: 3 months after surgery
Cup/ Disk ( C/ D）
determine the cup to disc ratio by ophthalmoscope
Time frame: 3 months after surgery
Plan to share: No — Individual participant data (IPD) needed to be keep security.
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This study is status unknown, as verified in Feb 2022. You cannot join it, but the record below documents what was studied.
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