An observational study in Primary Angle-Closure Glaucoma, sponsored by Zhongnan Hospital. Recruiting at 1 site in China. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2026-04-20.
Sponsored by Zhongnan Hospital · Observational
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.
This study investigates the pathogenesis of PACG by conducting multi-omics analyses of aqueous humor, blood and anterior lens capsule samples from PACG patients with and without concomitant zonular abnormalities, aiming to elucidate the etiology of zonular abnormalities and uncover novel mechanisms underlying their involvement in the pathogenesis of glaucoma.
PACG patients with or without zonular laxity, as well as age-related cataract patients without a history or signs of glaucoma who served as the control group.
Exclusion Criteria:
PACG patients with zonular laxity
Other: No Additional Experimental Intervention
PACG patients without zonular laxity
Other: No Additional Experimental Intervention
cataract patients without a history or signs of glaucoma
Other: No Additional Experimental Intervention
No Additional Experimental Intervention
Concentration of differentially expressed molecules in PACG patients with zonular laxity
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and healthy control subjects, differentially expressed molecules will be identified and quantified by high-throughput omics sequencing and bioinformatics analysis in PACG patients with zonular laxity, and a potential mechanistic network will be constructed based on these molecular changes.
Time frame: 2 years
Plan to share: Undecided
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Zhongnan Hospital