An interventional study of Photorefractive Keratectomy with Corneal Cross-Linking in Keratoconus and Corneal Cross-Linking, sponsored by Shahid Beheshti University. Status unknown at 1 site in Iran, Islamic Republic of. Open to participants aged 30 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-04-18.
Sponsored by Shahid Beheshti University · Not applicable, Interventional, and Treatment
Interventional and comparative prospective study: Sixty-nine eyes (38 patients) suffering from keratoconus (stages 1-2 Amsler-Krumeich classification) will be divided into four groups. The four groups underwent topography- and non-topography-guided PRK with sequential and simultaneous CXL. The main outcome measures will be pre-and postoperative uncorrected distance visual acuity (UDVA), best-corrected distance visual acuity (CDVA), manifest refraction, contrast sensitivity, and keratometry
307 studies on the registry are indexed under Keratoconus; 56 are open to participants now.
This study's enrollment of 50 is above the median of 40 across 203 interventional studies indexed under Keratoconus.
Browse Keratoconus studies →Shahid Beheshti University is the lead sponsor of 35 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Inclusion criteria for the study focused on patients over 34 (range from 34 to 41) with stable corneal topography and refraction for at least six months and an estimated residual bed thickness of >410 µm.
exclusion from the study included the presence of macular or retinal disease, dry eye, history of recurrent corneal erosions, anterior segment abnormalities, unstable refractive error, post-surgically residual stromal bed thickness of under 350 mm, autoimmune disease, collagen vascular disease, immunosuppressive therapy, or current use of systemic corticosteroids, diabetes mellitus, pregnancy, and lactation.
For correction of refractive error
Procedure: Photorefractive Keratectomy with Corneal Cross-Linking
To our knowledge, this study is one of the first to compare the visual results of non-topography-guided and topography-guided photorefractive keratectomy (PRK) applying sequential and simultaneous corneal cross-linking (CXL) treatment for keratoconus. Considering recent advances in cross-linking and imaging in keratoconus, the outcomes of this study can lead us to several non-invasive algorithm management options.
Visual Acuity
Evaluation of the uncorrected visual acuity, best corrected visual acuity, astigmatism, intraocular pressure and endothelial cell loss before and after the last operation.
Time frame: 3 year
This study is status unknown, as verified in Jan 2022. You cannot join it, but the record below documents what was studied.
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Shahid Beheshti University