An observational study in Persistent Critical Illness, sponsored by Centre Hospitalier Universitaire Vaudois. Completed at 1 site in Switzerland. Open to participants aged 18 Years to 95 Years. Per ClinicalTrials.gov, last updated 2022-04-05.
Sponsored by Centre Hospitalier Universitaire Vaudois · Observational
The Corona Virus Disease-19 (COVID-19) pandemic has resulted in an overwhelming number of intensive care (ICU) patient admissions, generally for acute respiratory distress, often resulting in persistent critical illness (PCI). Little is known about their metabolic and nutritional characteristics compared to other non-COVID (non-CO) categories of patients.
The aim is to compare the metabolic characteristics and gastro-intestinal function of the previously admitted non-CO and COVID persistent critically ill patients, and the adherence to the ICU nutrition protocol.
Prospective observation study including two consecutive cohorts of PCI, defined by a prolonged mechanical ventilation requirement longer than 10days.
The metabolic and nutritional characteristics of the COVID-19 patients requiring prolonged ICU treatment compared to other non-COVID (non-CO) categories of patients remain poorly described. The aim was to compare the metabolic characteristics of the previously admitted non-CO and COVID PCI patients.
Prospective observation study including two consecutive cohorts of PCI, defined as requiring a mechanical ventilation for >10 days.
The comparative cohort is the first patient cohort previously registered as NCT03938961.
Variables: demographic data, severity score (SAPS2, organ failure (SOFA) scores), Nutrition Risk Screening (NRS) score, C-reactive protein (CRP), blood phosphate. Nutritional variables: energy intake (detail of protein, lipids, glucose), fasting time, feeding route, prealbumin values, bowel activity, insulin requirements Outcome: length of mechanical ventilation, ICU and hospital stay and outcome. Descriptive statistics
70 studies on the registry are indexed under Hypophosphatemia; 15 are open to participants now.
This study's enrollment of 110 is above the median of 92 across 27 observational studies indexed under Hypophosphatemia.
Browse Hypophosphatemia studies →Centre Hospitalier Universitaire Vaudois is the lead sponsor of 208 studies on the registry; 47 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Critically ill patients requiring prolonged ICU treatment
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Consecutive persistent critically ill patients requiring more than 10 days of mechanical ventilation, admitted just before the first COVID-19 wave
Other: Nutrition therapy according to ICU protocol
Consecutive persistent critically ill COVID-19 patients requiring more than 10 days of mechanical ventilation, admitted during the first COVID-19 wave
Other: Nutrition therapy according to ICU protocol
The study aims a verifying adherence to the ICU nutrition protocol
Energy balance
Delta between energy delivery and prescription
Time frame: up to 30 days
Feeding route and time to feeding
Proportion of days on enteral, parenteral, combined, oral feeding or fasting
Time frame: up to 30 days
Hypophosphataemia
Number of blood phosphate values \<0.8 mmol/l
Time frame: up to 30 days
Insulin resistance
Quantity of insulin required to maintain blood glucose with ICU targets
Time frame: up to 30 days
Bowel activity
Frequency of diarrhea and constipation
Time frame: up to 30 days
Length of ICU and hospital stay
length in days
Time frame: up to 3 months
Plan to share: No
No publications or documents are linked to this record.
Ran from Jul 2019 to primary completion in Dec 2020, 17 months.
Of 16 observational studies under Hypophosphatemia, half reached primary completion within 15 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 24. This study's 17 months is above that.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Apr 2022. You cannot join it, but the record below documents what was studied.
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