An interventional study of Rescue intracranial stenting in Acute Stroke, Ischemic Stroke and Intracranial Atherosclerosis, sponsored by Can Tho Stroke International Services Hospital. Completed at 1 site in Vietnam. Open to participants aged 20 Years to 105 Years. Per ClinicalTrials.gov, last updated 2021-09-13.
Sponsored by Can Tho Stroke International Services Hospital · Not applicable, Interventional, and Treatment
In acute ischemic stroke caused by intracranial large vessel occlusion, rescue intracranial stenting has been recently a treatment option to achieve recanalization in patients with the failure of mechanical thrombectomy. Nevertheless, there are few studies supporting this beneficial treatment in two cerebral circulations. We aimed to analyse whether the use of rescue intracranial stenting would improve prognosis of patients at 3 months.
In Asia population, large intracranial arterial stenosis lesion accounts for more than 30% in common causes of ischemic stroke, compares with about 10% in Caucasian population every year. Normally, in human brain, there are about 130 billion neurons but they are lost equivalent to their losses in approximately 3.6 years of normal aging in case of a large vessel ischemic stroke untreated each hour. Consequently, after the success of 5 randomized controlled trials about the mechanical thrombectomy, which have been done from December 2010 to December 2014, all of guidelines recommended this technique as the first-line treatment in acute ischemic stroke. However, the HERMES meta-analysis showed that revascularisation failure ratio 28.9% in patients older than 80 years. Recently, in case of mechanical thrombectomy failure, many studies suggested the rescue intracranial stenting could be alternative urgently needed treatment to achieve permanent recanalization which is one of the most important factors impacting on clinical outcomes after acute ischemic stroke. Hence, the aims of our study were to assess both the "non-poor" outcome at 3 months and the symptomatic intracerebral hemorrhage relating to procedure in patients receiving rescue intracranial stenting.
Exclusion Criteria:
RIS in Acute Ischemic Stroke caused by intracranial large vessel occlusion
Procedure: Rescue intracranial stenting
Rescue Intracranial Stenting in Acute Ischemic Stroke caused by intracranial large vessel occlusion
Also known as: RIS
The "non-poor" 3-month outcome rate.
The "non-poor" 3-month outcome rate was accessed by modified Rankin Score (mRS), which comprised of included good (mRS 0 - ≤ 2) and fair (mRS 3).
Time frame: 3 months
The symptomatic intracerebral hemorrhage rate.
The symptomatic intracerebral hemorrhage was defined as patient's intracerebral hemorrhage with postprocedural mRS ≥ 5 and there were no other evident causes for the increased mRS.
Time frame: 24 hours after rescue intracranial stenting.
Plan to share: No
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Can Tho Stroke International Services Hospital