An interventional study of Emergent Stenting in Acute Stroke and Ischemic Stroke, Acute, sponsored by Can Tho Stroke International Services Hospital. Recruiting at 1 site in Vietnam. Open to participants aged 19 Years to 100 Years. Per ClinicalTrials.gov, last updated 2024-06-13.
Sponsored by Can Tho Stroke International Services Hospital · Not applicable, Interventional, and Treatment
In acute ischemic stroke due to tandem occlusion, the emergent stenting has recently become an endovascular treatment option combining with mechanical thrombectomy to achieve recanalization. However, the data on the beneficial endovascular management of tandem occlusion in two circulations is still limited. The purpose of our study was to compare the improvement of clinical outcome between two circulations after emergent stenting at 3 months.
The posterior circulation (about 20 - 25%) is less frequent than the anterior one in the acute ischemic stroke, but high mortality and morbidity in the acute vertebrobasilar thrombosis even successful recanalization are revealed. Besides, tandem occlusion is one of the complex lesions in large vessel occlusions relating to the poor outcome, particularly in the posterior circulation. Recent studies have suggested that emergent stenting could be used as an additional treatment to achieve permanent recanalization together with mechanical thrombectomy in the intracranial segments. Permanent recanalization is one of the most important factors that impact patient outcomes after acute ischemic stroke. However, although there are various approaches for this lesion, the comparision of the effectiveness in the two circulations remains unclear. Thus, the aims of our study were to compare baseline characteristics and clinical outcome of tandem occlusions between anterior and posterior circulation after emergent stenting in extracranial arteries.
2,612 studies on the registry are indexed under Ischemic Stroke; 971 are open to participants now.
This study's planned enrollment of 110 is close to the median of 120 across 1,776 interventional studies indexed under Ischemic Stroke.
Browse Ischemic Stroke studies →Can Tho Stroke International Services Hospital is the lead sponsor of 8 studies on the registry; 1 is open to participants now.
Compared within Ischemic Stroke, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Stroke. The counts are of registry records indexed under each term, refreshed daily. How we classify →
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Exclusion Criteria:
Emergent Carotid Stenting in acute ischemic stroke caused by tandem occlusions
Procedure: Emergent Stenting
Emergent Extracranial Vertebral Stenting in acute ischemic stroke caused by tandem occlusions
Procedure: Emergent Stenting
Emergent Stenting in acute ischemic stroke caused by tandem occlusions
The favorable 3-month outcome rate
The favorable 3-month outcome rate was accessed by modified Rankin Score (mRS), which comprised of included good (mRS 0 - ≤ 2) and fair (mRS 3).
Time frame: 3 months
The symptomatic intracerebral hemorrhage rate
The symptomatic intracerebral hemorrhage was defined as patient's intracerebral hemorrhage with postprocedural mRS ≥ 5 and there were no other evident causes for the increased modified Rankin Score (mRS).
Time frame: 24 hours after emergent stenting
Plan to share: No
Started Dec 2020 (actual). Primary completion is estimated for Sep 2025, 57 months after the start.
Of 572 non-industry interventional studies with no phase under Ischemic Stroke, half reached primary completion within 28 months of starting (the median), counting those still running; a quarter within 14 and three quarters within 48. This study's planned 57 months is above that.
Counting every sponsor, half of 653 studies reached it within 27 months; a quarter within 14 and three quarters within 48.
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Can Tho Stroke International Services Hospital