An observational study in Aortic Valve Stenosis and Coronary Artery Disease, sponsored by Heart and Diabetes Center North-Rhine Westfalia. Recruiting at 1 site in Germany. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2024-11-26.
Sponsored by Heart and Diabetes Center North-Rhine Westfalia · Observational
Aortic valve stenosis (AS) affects 2-7% of persons > 65 years, symptoms include: angina and dyspnea, dizziness and syncope. Coincidence of coronary artery disease (CAD), also presenting with angina and dyspnea, in patients with AS between 40 - 65% . Angina in AS caused by significant reduction of coronary flow reserve (CFR). CFR is the ratio of maximal flow increase in the coronary vessel bed during maximal hyperaemia (medically or exercise induced). FFR (fractional flow reserve) use in patients with AS potentially invalid due to dysfunctional CFR leading to potential undertreatment of CAD in these patients.CFR disturbance in AS mainly due to myocardial overload causing concentric hypertrophy, increased oxygen consumption and neurohormonal activation leading to increased vascular resistance. Current studies are investigating the validity of FFR and iFR in AS patients. Recent data demonstrate very good correlation between FFR and iFR derived values to PET myocardial perfusion imaging values in patients with no evidence of AS. Our study aims to investigate the diagnostic performance of FFR and iFR in intermediate-grade coronary stenosis in patients with severe aortic valve disease and correlate FFR- and iFR derived values with those extracted from PET-perfusion Imaging.
5,596 studies on the registry are indexed under Coronary Artery Disease; 955 are open to participants now.
This study's planned enrollment of 20 is below the median of 336 across 1,946 observational studies indexed under Coronary Artery Disease.
Browse Coronary Artery Disease studies →Heart and Diabetes Center North-Rhine Westfalia is the lead sponsor of 33 studies on the registry; 5 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with severe aortic Stenosis eligible for transcatheter aortic Valve Implantation (TAVI) with concurring coronary artery disease.
Exclusion Criteria:
Correlation of PET-CT Prior to TAVI and 3 months after TAVI procedure
Evaluation of FFR-negative intermediary coronary stenoses in Patients with severe Aortic Stenosis Prior and 3 months following TAVI
Time frame: 3 months
Clinical Evaluation Prior to and following TAVI
Angina prevalence in patients with intermediate coronary Stenosis Prior to and 3 months following TAVI
Time frame: 3 months
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Heart and Diabetes Center North-Rhine Westfalia