An interventional study of diclofenac / acetaminophen /codeine and ibuprofen/acetaminophen/codeine in Impacted Third Molar Tooth and PAIN, sponsored by University of Zimbabwe. Suspended at 1 site in Zimbabwe. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-01-05.
Sponsored by University of Zimbabwe · Not applicable, Interventional, and Treatment
Among 37 studies testing diclofenac in Pain — 1 open to participants now, 1 under way, none of them phase 3. Diclofenac · Pain.
Among the 37 studies testing diclofenac in Pain, this one is the 20th largest by enrollment, is the only one that started in 2023, is one of 8 with no phase, and was the 32nd registered.
10,054 studies on the registry are indexed under Pain; 1,649 are open to participants now.
Browse Pain studies →1 of the 37 studies testing diclofenac in Pain is open now, in 1 country. Recruiting first, the newest first:
ZetrOZ, Inc. · Sites in United States
By country, each count listing its studies:
Diclofenac: first FDA approval 1988 (VOLTAREN). What it is approved for, and how studies give it, is on its page →
Of the 929 Pain studies recruiting now, 384 (41%) set no upper age limit and 434 (47%) stop at 75 or younger; 146 take children under 18; 222 take healthy volunteers.
This study: 18 Years and older · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
37 studies; the count open now beside each. This study's row is marked.
First in 2000; this study’s year is marked. 1 started in 2023.
This study's enrollment of 78 is above the median of 66 across 8,493 interventional studies indexed under Pain.
Median enrollment 80 across the 37 interventional studies. Of the 27 that completed or were terminated, 7 (26%) have results posted.
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12 of 37 have an industry lead sponsor. The 10 most frequent:
University of Zimbabwe is the lead sponsor of 18 studies on the registry; 2 are open to participants now.
University of Zimbabwe has 1 study filed under Pain — fewer than ten, so there is no comparison to draw.
None of the studies under way reaches primary completion within a year.
Among the 37 studies testing diclofenac in Pain, from their registry updates:
Nothing recorded among them since 2026-09-25.
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Randomised control clinical trial to compare which combination of analgesics in effective in pain management after third molar extraction of wisdom teeth. The study will assess post operative pain after third molar extraction of two groups of study participants who will be given one of the two combinations of Diclofenac/ acetaminophen/codeine and ibuprofen/acetaminophen/codeine .
Double blind randomized control clinical trial to compare the level of pain relief that occurs after third molar extraction done under local anaesthesia at the maxillofacial center, Harare, Zimbabwe. The participants will be randomized into two arms upon fitting the inclusion criteria.The pharmacist will be in charge of randomization and will randomise the participants upon giving them the medications. One group will receive combination of diclofenac/acetaminophen/codeine and the other group will receive ibuprofen/acetaminophen/codeine as post extraction analgesia.The dosages of the medications will be Diclofenac 50mg, ibuprofen 400mg, acetaminophen 500mg and codeine 15mg respectively. Questionnaires will be given to the patient to complete after discharge from the surgery and other parts of the questionnaire will be completed on review after 7 days. A record will be done of the postoperative pain experience (using visual analogue scale), use of rescue medication and details pertaining to impacted tooth.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
routine pain medication used in post extraction pain management
Drug: diclofenac / acetaminophen /codeine
routine pain medication used in post extraction pain management
Drug: ibuprofen/acetaminophen/codeine
Drug pages: Diclofenac · Acetaminophen · Codeine
routine pain medication used post extraction of third molars
Also known as: diclofenac/paracetamol/codeine phosphate
Drug pages: Ibuprofen · Acetaminophen · Codeine
routine pain medication used post extraction of third molars
Also known as: ibuprofen/paracetamol/codeine phosphate
post operative pain
record of pain felt by patients on Visual analogue scale using a smiling face to show no pain and worst pain ever with a sad face measured line at 100mm . a score of 100mm indication worst pain and score of 0mm indicating no pain.
Time frame: within 7 days post extraction
Time rescue medication is used
rescue medication
Time frame: within 7 days post extraction
cheek swelling
amount of cheek swelling post extraction
Time frame: with in 7 days post extraction
Plan to share: Undecided
No publications or documents are linked to this record.
Start is estimated for Mar 2023; primary completion for Dec 2023, 9 months later.
How these figures are worked out, and which studies are left out of them.
This study is suspended, as verified in Jan 2023. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Diclofenac · Acetaminophen · Codeine · Ibuprofen
University of Zimbabwe