CClinicalTrials.gg
CompletedNCT04649138Updated Apr 4, 2025

Fomepizole Dosing During Continuous Renal Replacement Therapy (CRRT)

An observational study in Toxic Alcohol Poisoning, sponsored by Oslo University Hospital. Completed at 1 site in Norway. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-04-04.

Sponsored by Oslo University Hospital · Observational

Study type
Observational
Model
Other
Time perspective
Prospective
Enrollment
11
Ages
18 Years and older
Sex
All
01

Study summary

The project is a prospective observation study of patients with suspected or confirmed toxic alcohol poisoning treated with fomepizole and continuous renal replacement therapy (CRRT)

02

Conditions studied

  • Toxic Alcohol Poisoning

Browse trials for

03

In context

Poisoning

209 studies on the registry are indexed under Poisoning; 26 are open to participants now.

This study's enrollment of 11 is below the median of 121 across 94 observational studies indexed under Poisoning.

Browse Poisoning studies →

Lead sponsor

Oslo University Hospital is the lead sponsor of 810 studies on the registry; 148 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Toxic alcohol poisoning treated with fomepizole and CRRT.

Inclusion criteria

  • Patients (over 18 year) with suspected or confirmed toxic alcohol poisoning treated with fomepizole and CRRT.

Exclusion criteria

Exclusion Criteria:

  • Patients who wish to withdraw from the study
05

Study design

Observational model
Other
Time perspective
Prospective
Enrollment
11 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Measure minimum plasma concentration of fomepizole

    Plasma samples will be obtained up to every hour and before fomepizole is given

    Time frame: through study completion, up to 72 hours

Secondary outcomes

  1. Continuous renal replacement therapy (CRRT) clearance of fomepizole

    Plasma and dialysat samples will be obtained up to every hour

    Time frame: through study completion, up to 72 hours

  2. Determine saturation/sieving coefficient of fomepizole

    Plasma and dialysat samples will be obtained up to every hour

    Time frame: through study completion, up to 72 hours

07

Study locations

1 site
  • Oslo University Hospital
    Oslo, Norway
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 4, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04649138
Lead sponsor
Oslo University Hospital
Collaborators
Louisiana State University Health Sciences Center Shreveport
Responsible party
Knut Erik Hovda, MD, PhD (Principal Investigator, Oslo University Hospital) — Principal investigator
First posted
Dec 2, 2020
Start date
Jun 13, 2019
Primary completion
Nov 26, 2020
Completion
Nov 26, 2020
Last update
Apr 4, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2020. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion