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CompletedNCT04509869Updated Aug 14, 2020

"Outcome of Varicocelectomy on Normal Semen in Patients Complaining of Orchialgia

An interventional study of varicocelectomy in Varicocele, Pain and Fertility Issues, sponsored by Assiut University. Completed at 1 site in Egypt. Open to male participants aged 19 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-08-14.

Sponsored by Assiut University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 2 years 11 months after the study started (first participant enrolled Aug 2017, registered Aug 2020).
Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Not applicable
Ages
19 Years to 50 Years
Sex
Male
01

Study summary

varicoclelectomy is done for subfertiltiy and varicocele induced orchialgia. The effect of varicocelectomy on semen analysis is controversial. Many articles report favorable outcomes and others do not.

Most study don't focus on varicocelectomy done for varicocele induced orchialgia,and those studies dont report on postoperative semen.

This study will focus on the effect of operation on the semen postoperatively .

02

Conditions studied

  • Varicocele
  • Pain
  • Fertility Issues
03

In context

Varicocele

53 studies on the registry are indexed under Varicocele; 15 are open to participants now.

This study's enrollment of 20 is below the median of 72 across 36 interventional studies indexed under Varicocele.

Browse Varicocele studies →

Lead sponsor

Assiut University is the lead sponsor of 5,078 studies on the registry; 2,178 are open to participants now.

Of its 14 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Browse Assiut University studies →

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
19 Years to 50 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Primary varicocele
  2. Patient's age more than 19 years
  3. Normal semen analysis (according to the WHO 5th guide to semen parameters where sperm concentration equal 15 million per ml , total sperm number 40 million per ejaculate ,normal morphology 4 % and motility A =25% or a+b = 32% is considered normal.
  4. Scrotal pain after exclusion of other causes.

Exclusion criteria

Exclusion Criteria:

  • 1- Recurrent varicocele
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
20 participants (actual)

Study arms

  • Experimental
    pre-operative and postoperative

    the patients who will undergo the operation to treat the pain

    Procedure: varicocelectomy

Interventions

  • Procedurevaricocelectomy

    operation for varix ligation

06

What researchers measure

Primary outcomes

  1. sperm motility

    semen analysis will be done preoperative and post-operative

    Time frame: 3 months postoperative is our aim

  2. sperm morphology

    semen analysis will be done preoperative and postoperative

    Time frame: 3 months postoperative is our aim

  3. sperm number

    semen analysis will be done preoperative and postoperative

    Time frame: 3 months postoperative is our aim

  4. pain of scrotum

    subjective sensation measured by visual analogue score preoperative and postoperative

    Time frame: 3 months postoperative is our aim

07

Study locations

1 site
  • Assuit Medical School
    Assiut, Assuit 71621, Egypt
08

References and documents

Publications

  • Chen SS. Factors predicting symptomatic relief by varicocelectomy in patients with normospermia and painful varicocele nonresponsive to conservative treatment. Urology. 2012 Sep;80(3):585-9. doi: 10.1016/j.urology.2012.05.014. Epub 2012 Jul 10. PubMed 22784493 ↗
  • Abd Ellatif ME, Asker W, Abbas A, Negm A, Al-Katary M, El-Kaffas H, Moatamed A. Varicocelectomy to treat pain, and predictors of success: a prospective study. Curr Urol. 2012 May;6(1):33-6. doi: 10.1159/000338867. Epub 2012 Mar 18. PubMed 24917707 ↗
  • Cho CL, Esteves SC, Agarwal A. Indications and outcomes of varicocele repair. Panminerva Med. 2019 Jun;61(2):152-163. doi: 10.23736/S0031-0808.18.03528-0. PubMed 30990285 ↗
  • Maghraby HA. Laparoscopic varicocelectomy for painful varicoceles: merits and outcomes. J Endourol. 2002 Mar;16(2):107-10. doi: 10.1089/089277902753619627. PubMed 11962551 ↗
  • Peterson AC, Lance RS, Ruiz HE. Outcomes of varicocele ligation done for pain. J Urol. 1998 May;159(5):1565-7. doi: 10.1097/00005392-199805000-00043. PubMed 9554356 ↗
  • Yaman O, Ozdiler E, Anafarta K, Gogus O. Effect of microsurgical subinguinal varicocele ligation to treat pain. Urology. 2000 Jan;55(1):107-8. doi: 10.1016/s0090-4295(99)00374-x. PubMed 10654904 ↗

Individual participant data

Plan to share: Undecided

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 14, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04509869
Lead sponsor
Assiut University
Responsible party
Abdelrahman Mohamed Abdelkader (chief resident of urology, Assiut University) — Principal investigator
First posted
Aug 12, 2020
Start date
Aug 12, 2017
Primary completion
Aug 12, 2020
Completion
Aug 12, 2020
Last update
Aug 14, 2020

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2020. You cannot join it, but the record below documents what was studied.

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