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CompletedNCT04489394QuintexUpdated Apr 9, 2024

Quintex® Follow-up After One Year Minimum

An observational study in Degenerative Disc Disease, Spondylolisthesis and Trauma, sponsored by Aesculap AG. Completed at 1 site in Germany. Per ClinicalTrials.gov, last updated 2024-04-09.

Sponsored by Aesculap AG · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
60
Sex
All
01

Study summary

Prospective study, not randomised, non-interventional, monocentric, investigating an intended patient cohort of 60 patients already operated on the cervical spine due to degenerative disc disease of the cervical spine down to the first thoracolumbar VBR (C2-T1), who received a Quintex plate for stabilisation

02

Conditions studied

  • Degenerative Disc Disease
  • Spondylolisthesis
  • Trauma
  • Spinal Stenosis
  • Deformity of Spine
  • Pseudoarthrosis of Spine
  • Cervical Spondylosis
  • Instability; Back
03

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

adult patients

Inclusion criteria

  • all patients who received a Quintex® Anterior Cervical Plate since 2014 until approx. end 2018 (minimum Follow-up is one year) in the study center

Exclusion criteria

Exclusion Criteria:

  • Patient informed consent not signed
  • Patients living outside a radius of 80 km around the study center
04

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
60 participants (actual)
05

What researchers measure

Primary outcomes

  1. Clinical Results measured by Neck Disability Index (NDI)

    The NDI is designed to measure neck-specific disability. The questionnaire has 10 items to measure patient-reported disability secondary to neck pain and activities of daily living including personal care, lifting, reading, headaches, concentration, work status, driving, sleeping and recreation and patients rate their status from 0 (best) to 5 (worst imaginable). Individual item responses are summed to a total score, where 0 points indicate no activity limitations and 50 points indicate complete activity limitation.

    Time frame: One retrospective visit, between one and approx. five years post-op.

Secondary outcomes

  1. Neck and arm pain

    Visual analogue scale for pain: The visual analogue scale (VAS) is a scale used to determine the pain intensity experienced by individuals. It consists of a line, approximately 10-15 cm in length, with the left side signifying no pain with a smiling face image and the right side signifying the worst pain ever with a frowning face image.

    Time frame: One retrospective visit, between one and approx. five years post-op.

  2. Patient satisfaction

    Patient satisfaction with Outcome of surgery documented in two aspects: is the Patient satisfied (four Point scale: very satisfied, satisfied, unsatisfied, very unsatisfied) and would the Patient like to undergo surgery again (yes, no, not willing to say)

    Time frame: One retrospective visit, between one and approx. five years post-op.

  3. Quality of life measured by EQ-5D-5L

    The descriptive system comprises five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/ depression. Each dimension has 5 levels: no problems, slight problems, moderate problems, severe problems and extreme problems. The patient is asked to indicate his/her health state by ticking the box next to the most appropriate statement in each of the five dimensions. This decision results in a 1-digit number that expresses the level selected for that dimension. The digits for the five dimensions can be combined into a 5-digit number that describes the patient's health state.

    Time frame: One retrospective visit, between one and approx. five years post-op.

  4. Dysphagia assessment

    Bazaz score: The Bazaz Dysphagia Score is one criterion used to define dysphagia; it classifies dysphagia as severe, moderate, mild, or none

    Time frame: One retrospective visit, between one and approx. five years post-op.

  5. Complications

    Adverse Events and Serious Adverse Events, reoperations and revisions rates

    Time frame: One retrospective visit, between one and approx. five years post-op.

  6. Postoperative Need for Pain medication

    The patient's Need for Pain Medication is measured by the WHO (World Health Organization) analgesic ladder

    Time frame: One retrospective visit, between one and approx. five years post-op.

  7. Radiological outcome from standard x-rays

    Radiologically: Fusion status, plate position, pot. migration of screws and plate, radiolucent lines

    Time frame: One retrospective visit, between one and approx. five years post-op.

06

Study locations

1 site
  • Katholisches Klinikum Koblenz
    Koblenz, 56073, Germany
07

References and documents

Publications

  • Bruchmann B, Kilian F. Follow-up of a new titanium cervical plate for fusion of the cervical spine. Orthop Rev (Pavia). 2023 Oct 12;15:84651. doi: 10.52965/001c.84651. eCollection 2023. PubMed 37842541 ↗
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Registry details

Key details

Study ID
NCT04489394
Lead sponsor
Aesculap AG
Responsible party
Sponsor
First posted
Jul 28, 2020
Start date
Nov 11, 2019
Primary completion
Feb 18, 2020
Completion
Feb 18, 2020
Last update
Apr 9, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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