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CompletedNCT04437355Updated Oct 26, 2022

Operative Treatment of Ankle Fractures

An interventional study of Specific provocation test in Ankle Fracture, Trimalleolar, Ankle Fracture - Lateral Malleolus and Ankle Fracture, Bimalleolar, sponsored by Spital Limmattal Schlieren. Completed at 1 site in Switzerland. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-10-26.

Sponsored by Spital Limmattal Schlieren · Not applicable, Interventional, and Diagnostic

Phase
Not applicable
Study type
Interventional
Enrollment
90
Allocation
Non-randomized
Ages
18 Years to 50 Years
Sex
All
01

Study summary

Patients who underwent operative treatment of an ankle fracture with or without following removal of the osteosynthetic material are examined by a specific ankle provocation test, a questionnaire and X-Rays to evaluate the clinical, functional and radiological outcome compared to a healthy control group

Read the detailed description

The study includes all patients operated from 09.12.2012 to 31.12.2020. Patients will undergo an X-Ray at least two years after primary surgery or at least one year after removal of the osteosynthetic material. The patients operated from 09.12.2012 to date are therefore a retrospective cohort, the patients from to date until 31.12.2020 a prospective cohort. This method is used to achieve the highest possible number of patients in a define period of time with no alteration of surgical technique.

All patients in the retrospective cohort are contacted at least 2 years after surgery (or 1 year after removal) via phone call or letter, informed about the study and asked to participate. In case of informed consent, they are invited to the study site. They are asked to complete the questionnaires and they undergo X-Ray of the affected and the non-affected ankle.

All patients in the prospective cohort are informed about the study and asked to participate in the outpatient clinic. In case of informed consent, they are invited to the study site at least 2 years after surgery. They are asked to complete the questionnaires and they undergo na X-Ray of the affected and non-affected ankle.

02

Conditions studied

  • Ankle Fracture, Trimalleolar
  • Ankle Fracture - Lateral Malleolus
  • Ankle Fracture, Bimalleolar
03

Who can participate

Ages eligible
18 Years to 50 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Age older than 18 and younger than 51 years
  • Operative treatment of an ankle fracture
  • Time operation to follow up: at least 2 years
  • Time removal of osteosynthetic material to follow up: at least 1 year
  • Time operative treatment to removal of the osteosynthetic material: at least 9 months
  • Informed Consent as documented by signature (Appendix: Informed Consent Form)

Exclusion criteria

Exclusion Criteria:

  • Other pathologies of the lower limb of the affected and/or non-affected side (fractures, pre-existing arthrosis or operative treatment of the affected and/or non-affected limb)
  • Pre-existing vascular (peripheral arterial disease, diabetes) or neurological diseases of the lower extremities
  • Women who are pregnant
  • Prevalence of an infection of the implanted osteosynthetic material
04

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
90 participants (actual)

Study arms

  • Active comparator
    Control Group

    Young and healthy Group of People (18-50 years) without any pathology of the lower limb

    Diagnostic Test: Specific provocation test

  • Active comparator
    Ankle Fracture Type Weber B

    Young and healthy patients with an operative treated fracture of the ankle (type Weber B)

    Diagnostic Test: Specific provocation test

  • Active comparator
    Ankle Fracture Weber C and complex

    Young and healthy patients with an operative treated fracture of the ankle (type Weber C or complex fracture)

    Diagnostic Test: Specific provocation test

Interventions

  • Diagnostic testSpecific provocation test

    To compare the results the investigators invite a healthy control group matching in age and gender with the intervention cohort. The control group is informed about the study and asked to participate in the outpatient clinic. In case of informed consent, the participants are invited to the study site. The participants undergo the same provocation test of the ankle, and are asked to complete the specific provocation test. In case of substantial underachievement in the provocation test (\<60% of maximum) an X-Ray of both ankles in a.p. and lateral projection is performed. The aim is to radiologically analyse the ankles, and to rule out any morphological reasons for the above mentioned underperformance.

05

What researchers measure

Primary outcomes

  1. Functional outcome

    This outcome will be compared with a group of adults matching in terms of gender and age. Measured by: - a specific ankle provocation test: Multiple sport test measuring possible movement of the ankle and tolerating stress simulating in sportive movement such as weight bearing, leg press tests etc. The specific provocation test does not have a specific name, because it is self made.

    Time frame: at least two year after surgery or one year after removal of the osteosynthetic material

  2. Functional outcome

    This outcome will be compared with a group of adults matching in terms of gender and age. Measured by: - three questionnaires (quality of life, possible movement, restrictions in daily life etc.)

    Time frame: 24 months after initial operation

Secondary outcomes

  1. Clinical outcome 1

    - VAS: Visual analogue score 1-10 Explanation: 1 means almost no pain, 10 is the worst pain one can imagine

    Time frame: 24 months after initial operation

  2. Clinical outcome 2

    - Quality of life questionnaire Explanation: The SF-36 consists of eight scaled scores, which are the weighted sums of the questions in their section. Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower the score the more disability. The higher the score the less disability i.e., a score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability. To calculate the scores it is necessary to purchase special software for the commercial version, but no special software is needed for the RAND-36 version. Pricing depends on the number of scores that the researcher needs to calculate.

    Time frame: 24 months after initial operation

  3. Clinical outcome 3

    * Arthrosis compared to the non-affected ankle measured by X-Ray (after an ankle fracture followed by an operative Treatment) * The measurement consists of evaluation the joint congruency, quality of the bone and the cartilage and the clear spaces (medial, central, lateral).

    Time frame: 24 months after initial operation

Other outcomes

  1. Specific ankle provocation test

    specific provocation test in our department of physiotherapy supervised by a physiotherapist and one of the investigators. measure of weight bearing, jump on one feet, balance.

    Time frame: 24 months after initial operation

06

Study locations

1 site
  • Spital Limmattal
    Schlieren, Zurich 8952, Switzerland
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT04437355
Lead sponsor
Spital Limmattal Schlieren
Responsible party
Prof Urs Zingg (Head of Department of surgery, Spital Limmattal Schlieren) — Principal investigator
First posted
Jun 18, 2020
Start date
Jul 1, 2018
Primary completion
Dec 31, 2021
Completion
Dec 31, 2021
Last update
Oct 26, 2022

Study contacts

Urs Zingg
study chair · Spital Limmattal Schlieren

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
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