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CompletedNCT04435340Updated Apr 13, 2023

Ventral Abdominal Hernia Repair With Self Adhering, Atraumatic Mesh

An interventional study of Selective Sonography of the ventral abdominal hernia level in Abdominal Hernia, sponsored by Spital Limmattal Schlieren. Completed at 1 site in Switzerland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2023-04-13.

Sponsored by Spital Limmattal Schlieren · Not applicable, Interventional, and Diagnostic

Phase
Not applicable
Study type
Interventional
Enrollment
100
Allocation
Non-randomized
Ages
18 Years and older
Sex
All
01

Study summary

Patients who underwent ventral abdominal hernia repair with self adhering, atraumatic mesh in sublay position are examined for their recurrence rate

Read the detailed description

The study includes all patients operated from 11.03.2014 to 31.12.2020. Patients will undergo a Sonography at least one year after surgery. The patients operated form 11.03.2014 to date are therefore a retrospective cohort, the patients from to date until 31.12.2020 a prospective cohort. This method is used to achieve the highest possible number of patients in a define period of time with no alteration of surgical technique.

All patients in the retrospective cohort are contacted at least 1 year after surgery and/or 3 years after surg ery via phone call or letter, informed about the study and asked to participate. In case of informed consent, they are invited to the study site. They are asked to complete the questionnaires and they undergo a Sonography of the ventral abdomen.

All patients in the prospective cohort are informed about the study and asked to participate in the outpatient clinic before surgery. In case of informed consent, they are invited to the study site at least one year and three years, respectively, after surgery. They are asked to complete the questionnaires and they undergo an ultrasound of the ventral abdomen.

The latest follow up should be completed by 31.03.2022.

For both, the retro- and prospective arm, the time needed for the follow-up appointment is approximately 1 hour. The completion of the ultrasound is estimated to take 20 minutes, the questionnaires is estimated to take 20-30 minutes.

02

Conditions studied

  • Abdominal Hernia

Keywords

  • Abdominal Hernia
  • Ventral Hernia
  • Atraumatic mesh
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Age older than 18 years
  • Initially suffering from ventral abdominal hernia
  • Performance of open ventral abdominal hernia repair with self-adhering, atraumatic mesh (Adhesix ®)
  • Informed Consent as documented by signature (Appendix: Informed Consent Form)

Exclusion criteria

Exclusion Criteria:

  • Inability to comply with the study protocol
04

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Non-randomized
Intervention model
Single group
Masking
Single (Participant)
Enrollment
100 participants (actual)

Study arms

  • Other
    Retrospective

    All patients in the retrospective cohort are contacted at least 1 year after surgery and/or 3 years after surgery via phone call or letter, informed about the study and asked to participate. In case of informed consent, they are invited to the study site. They are asked to complete the questionnaires and they undergo a Sonography of the ventral abdomen.

    Diagnostic Test: Selective Sonography of the ventral abdominal hernia level

  • Other
    Prospective

    All patients in the prospective cohort are informed about the study and asked to participate in the outpatient clinic before surgery. In case of informed consent, they are invited to the study site at least one year and three years, respectively, after surgery. They are asked to complete the questionnaires and they undergo an ultrasound of the ventral abdomen.

    Diagnostic Test: Selective Sonography of the ventral abdominal hernia level

Interventions

  • Diagnostic testSelective Sonography of the ventral abdominal hernia level

    The primary outcome of the study is measured by an radiologist experienced in abdominal ultrasound with a linear ultrasound transducer (ML 6-15 Hz). In case of aggravated examination circumstances a different ultrasound transducer is used (linear 9 L or convex C 1-6 Hz)

05

What researchers measure

Primary outcomes

  1. Recurrance rate in sonography

    The primary outcome is the recurrence rate of ventral abdominal hernia determined by clinical examination and sonography. A recurrence is defined if intraabdominal structures (i.e. intestines, omentum, preperitoneal fat tissue) reach ventrally of the facial layers .

    Time frame: 12 months after surgery

  2. Recurrance rate clinically

    The primary outcome is the recurrence rate of ventral abdominal hernia determined by clinical examination. A recurrence is defined if intraabdominal structures (i.e. intestines, omentum, preperitoneal fat tissue) reach ventrally of the facial layers .

    Time frame: 12 months after surgery

Secondary outcomes

  1. Pain and sensation of the mesh measured by the Carolinas Comfort Scale questionnaire

    Clinical subjective outcome 1

    Time frame: 12 months after surgery

  2. Limitations in quality of life questionnaire

    Clinical subjective outcome 2

    Time frame: 12 months after surgery

  3. Daily activities measured HerQLes questionnaire

    Clinical subjective outcome 3

    Time frame: 12 months after surgery

06

Study locations

1 site
  • Spital Limmattal
    Schlieren, Zurich 8952, Switzerland
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT04435340
Lead sponsor
Spital Limmattal Schlieren
Responsible party
Prof Urs Zingg (Head of Department of Surgery, Spital Limmattal Schlieren) — Principal investigator
First posted
Jun 17, 2020
Start date
Mar 22, 2018
Primary completion
Dec 31, 2022
Completion
Dec 31, 2022
Last update
Apr 13, 2023

Study contacts

Urs Zingg
study chair · Spital Limmattal Schlieren

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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