An observational study in Proton Pump Inhibitor Adverse Reaction, Hypomagnesemia and Arrhythmias, Cardiac, sponsored by Changi General Hospital. Completed at 1 site in Singapore. Open to participants aged 14 Years to 100 Years. Per ClinicalTrials.gov, last updated 2020-06-11.
Sponsored by Changi General Hospital · Observational
Use of proton pump inhibitors has been associated with hypomagnesemia. However, various case-control or prospective studies have found conflicting results with regards to proton pump inhibitors use and development of hypomagnesemia. Our aim was to evaluate the likelihood that proton pump inhibitors contributed to severe hypomagnesemia in a retrospective cohort of patients admitted with severe hypomagenesemia. We also aimed to look for risk factors leading to development of hypomagnesemia amongst users of proton pump inhibitors
881 studies on the registry are indexed under Seizures; 143 are open to participants now.
This study's enrollment of 211,672 is above the median of 150 across 235 observational studies indexed under Seizures.
Browse Seizures studies →Changi General Hospital is the lead sponsor of 98 studies on the registry; 18 are open to participants now.
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Patients managed at a referral centre from 2013 - 2016. Cases were admitted to the referral centre and had documentation hypomagnesemia. Controls were prescribed a course of proton pump inhibitor during the same period
Exclusion Criteria:
Patients admitted with hypomagnesemia are evaluated for proton pump inhibitor use and likelihood of hypomagnesemia due to proton pump inhibitor use
Drug: proton pump inhibitor use
Patients on long-term proton pump inhibitor without documented hypomagnesemia
Drug: proton pump inhibitor use
Patients using long term proton pump inhibitor
Hypomagnesemia due to use with proton pump inhibitor
Number of patients with Hypomagnesemia related to use of proton pump inhibitor using Naranjo score
Time frame: 2013 to 2016
Risk factors for Hypomagnesemia
Odds ratio of developing Hypomagnesemia with risk factors of age, gender, type of drug, dose of drug, chronic renal failure, use of diuretics
Time frame: 2013 to 2016
Hypocalcaemia
Number of patients developing hypocalcemia
Time frame: 2013 to 2016
Hypokalemia
Number of patients developing Hypokalemia
Time frame: 2013 to 2016
Plan to share: Undecided — Anonymised pooled data
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This study is completed, as verified in Jun 2020. You cannot join it, but the record below documents what was studied.
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Changi General Hospital