An interventional study of Transcranial Magnetic Stimulation in Stroke, Brain Disease and Central Nervous System Diseases, sponsored by VA Office of Research and Development. Recruiting at 1 site in United States. Open to participants aged 45 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-02.
Sponsored by VA Office of Research and Development · Not applicable, Interventional, and Treatment
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Among 87 studies in Stroke by VA Office of Research and Development — 13 open to participants now, 17 under way, none of them phase 3. Stroke · VA Office of Research and Development.
Among the 87 studies in Stroke by VA Office of Research and Development, this one is the 16th largest by planned enrollment of the 79 interventional ones that give a count, is one of 6 that started in 2020, is one of 67 with no phase, reaches primary completion later than 2 of the 16 other live ones, and was the 63rd registered.
8,258 studies on the registry are indexed under Stroke; 2,055 are open to participants now.
Browse Stroke studies →13 of the 87 studies in Stroke by VA Office of Research and Development are open now, in 1 country. Recruiting first, the newest first:
VA Office of Research and Development · Sites in United States
Ages 40–80
VA Office of Research and Development · Sites in United States
Ages 21+
VA Office of Research and Development · Sites in United States
Ages 18–80
VA Office of Research and Development · Sites in United States
Ages 18+ · Healthy volunteers
VA Office of Research and Development · Sites in United States
Ages 40–80
By country, each count listing its studies:
Of the 1,415 Stroke studies recruiting now, 695 (49%) set no upper age limit and 280 (20%) stop at 75 or younger; 77 take children under 18; 195 take healthy volunteers.
This study: 45 Years to 90 Years · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
87 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 7 · Phase 2 8 · Phase 3 1
First in 1999; this study’s year is marked. 6 started in 2020.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 76 is above the median of 49 across 6,027 interventional studies indexed under Stroke.
Median enrollment 38 across the 79 interventional studies, 56 across the 8 observational. Of the 67 that completed or were terminated, 60 (90%) have results posted.
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VA Office of Research and Development is the lead sponsor of 1,771 studies on the registry; 392 are open to participants now.
Of its 213 completed or terminated interventional studies of FDA-regulated products, 185 (87%) have results posted.
9 of the studies in Stroke by VA Office of Research and Development that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06400186VA Office of Research and DevelopmentMovement Amplification Gait Training to Enhance Walking Balance Post-Stroke | 2026-12-31 |
| NCT05983185VA Office of Research and DevelopmentPrism Adaptation Therapy (PAT) for Right Brain Stroke Rehabilitation | 2026-12-31 |
| NCT05760885VA Office of Research and DevelopmentMultisensory Augmentation for Post-stroke Standing Balance | 2027-01-01 |
| NCT05628324VA Office of Research and DevelopmentEMG-Controlled Game to Retrain Upper Extremity Muscle Activation Patterns Following Stroke | 2027-03-31 |
| NCT05296408VA Office of Research and DevelopmentExoskeleton Research: Myoelectric Orthosis for Rehab of Severe Chronic Arm Motor Deficits | 2027-04-01 |
Add all 9 to your calendar (.ics) → With an account.
Among the 87 studies in Stroke by VA Office of Research and Development, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The purpose of this study is to use Transcranial Magnetic Stimulation (TMS) while subjects are making reaching movements in a robotic arm device in order to discover how different brain areas control movement before and after stroke and when these brain areas are most sensitive to TMS.
The general objective of this application is to study reorganization of network interactions following a common type of subcortical stroke (i.e. internal capsule) with mechanistic studies using noninvasive neurophysiology in humans. The goal is to obtain pilot data and to demonstrate the feasibility of the approach that combines transcranial magnetic stimulation (TMS) with reaching in an advanced exoskeleton robot. As reaching is an essential part of many daily activities, this approach will have beneficial impacts on the quality of life of these stroke patients.
The central hypothesis is that bilateral premotor cortical areas, dorsal (PMd) more so than ventral (PMv,) develops greater connectivity with primary motor cortex (M1) after stroke and thus better ability to produce motor outputs that support reaching with the paretic arm. When there is more damage to the corticospinal tract, contralesional areas will take on a greater role.
The relationship between connectivity, behavioral effects of stimulation and motor performance will be established. These findings will allow the investigators to formulate clear hypotheses about which premotor area should be modulated with TMS, depending on stroke extent and deficits in motor control, when reaching the stage of proposing a treatment trial. Increased knowledge of the dynamic changes of physiological interactions during various phases of reaching movements will allow a more defined study regarding the role of premotor areas in recovery of motor function after stroke, and a novel treatment protocol that delivers precisely timed stimulations during practice of reaching movements. Ultimately, the investigators can test these novel treatments in clinical trials and compare their impact to other, less specific, neuromodulatory methods such as transcranial direct current stimulation. This study will also lay the groundwork for collaboration in brain computer interface and non-human primate investigations in the mechanisms and treatment of motor deficits after stroke.
Inclusion Criteria:
Inclusion Criteria (control participants):
Inclusion Criteria (participants with stroke):
Exclusion Criteria:
(for both groups)
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
All participants enrolled in this group will receive TMS while performing reaching movements in a robotic system.
Device: Transcranial Magnetic Stimulation
Paired pulse transcranial magnetic stimulation
Path length
Movement path length in centimeters from KINARM system during the one second reaching period. (units: cm)
Time frame: Immediate (within 2 s after stimulation)
Times
Specific kinematic data from KINARM system: reaction time, movement time to reach target (units: ms)
Time frame: Immediate (within 2 s after stimulation)
Velocities
maximum velocity reached during reach (units: cm/s)
Time frame: Immediate (within 2 s after stimulation)
Accuracy
specific position data from KINARM system: target accuracy, distance from manipulandum position at end of one second reaching period to target center. (units: cm.)
Time frame: Immediate (within 2 s after stimulation)
EMG
Electromyographic data from surface electrodes on biceps, triceps, anterior deltoid, and posterior deltoid muscles - These signals will be rectified and normalized to the maximum values during practice reaches. (units: mV/mV - dimensionless).
Time frame: Immediate (within 2 s after stimulation)
Plan to share: No — Research information will not be shared with anyone outside of the research team.
Started Jan 2020 (actual). Primary completion is estimated for Sep 2026, 79 months after the start.
Of 3,111 non-industry interventional studies with no phase under Stroke, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 46. This study's planned 79 months is above that.
Counting every sponsor, half of 3,255 studies reached it within 23 months; a quarter within 10 and three quarters within 46.
How these figures are worked out, and which studies are left out of them.
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