An observational study in Chronic Periodontitis and Smoking, Cigarette, sponsored by Ondokuz Mayıs University. Completed at 1 site in Turkey. Open to participants aged 35 Years to 60 Years. Per ClinicalTrials.gov, last updated 2019-10-04.
Sponsored by Ondokuz Mayıs University · Observational
This study was performed to evaluate the effects of both periodontal treatment and smoking on the gingival crevicular fluid(GCF) levels of interleukin (IL)-17A, IL-17E, Total oxidative stress(TOS) and total antioxidant capasity(TAOC) in smoking and non-smoking patients with severe chronic periodontitis.
Systemically healthy 15 smoker,15 non-smoker with chronic periodontitis were attended for the study. Periodontal status were determined by recording periodontal clinical measurements. GCF samples were collected at the baseline, at the end of initial periodontal treatment and 4 weeks after periodontal flap surgery. The data were tested statistically by the Student t and paired sample t tests.
1,634 studies on the registry are indexed under Periodontitis; 327 are open to participants now.
This study's enrollment of 30 is below the median of 89 across 427 observational studies indexed under Periodontitis.
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Patients with chronic periodontitis (with an age range of 35 to 60 years) seeking dental treatment at the Periodontology Clinic, School of Dentistry, Ondokuz Mayis University, were included in the present study.
Exclusion Criteria:
Individuals clinically diagnosed with chronic periodontitis that smoke recruited for this group.
Individuals clinically diagnosed with chronic periodontitis that don't smoke recruited for this group.
GCF IL-17A VOLUME
IL-17A is a cytokine present in gingival crevicular fluid. Its volume calculated as microliter and changes due to inflammation caused by periodontal disease.
Time frame: GCF sampling was performed prior to periodontal treatment , 4 weeks after completion of initial periodontal treatment, and 4 weeks after periodontal flap surgery .
GCF IL-17E VOLUME
IL-17E is a cytokine present in gingival crevicular fluid. Its volume calculated as microliter and changes due to inflammation caused by periodontal disease.
Time frame: GCF sampling was performed prior to periodontal treatment , 4 weeks after completion of initial periodontal treatment, and 4 weeks after periodontal flap surgery .
GCF TOTAL OXIDATIVE STRESS (TOS) LEVEL
TOS is the measurement of oxidative stress amount and given as mmol/L unit. Its amount changes due to inflammation caused by periodontal disease.
Time frame: GCF sampling was performed prior to periodontal treatment , 4 weeks after completion of initial periodontal treatment, and 4 weeks after periodontal flap surgery .
GCF TOTAL ANTIOXIDANT CAPASITY (TAOC)
TAOC is the antioxidant amount measured and given as μmol H2O2 Eq/L unit. Its amount changes due to inflammation caused by periodontal disease.
Time frame: GCF sampling was performed prior to periodontal treatment , 4 weeks after completion of initial periodontal treatment, and 4 weeks after periodontal flap surgery .
This study is completed, as verified in Oct 2019. You cannot join it, but the record below documents what was studied.
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Ondokuz Mayıs University