An observational study in Open Angle Glaucoma, Normal Tension Glaucoma and Healthy, sponsored by University of Zurich. Completed at 1 site in Switzerland. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-06-05.
Sponsored by University of Zurich · Observational
In addition to intraocular pressure blood perfusion pressure in the optic nerve is an important factor determing the cause of glaucoma. Increasing evidence suggests that in glaucoma patients retinal blood may be decreased.
According to the World Health Organization (WHO) glaucoma is the second leading cause of blindness. Glaucoma is a global problem, which is becoming even more important as the human life expectancy increases. Although the causes of glaucoma are uncertain, mainly intraocular pression (IOP), genetics, and ocular blood perfusion pressure in the optic nerve determine the cause of the disease. Increasing evidence suggests that in glaucoma patients retinal blood flow is decreased leading to progression and to damage of the optic nerve.
In order to measure the peripapillary blood flow a variety of devices using different techniques of flowmetry have been developed. In this study, the reproducibility of the retinal flowmetry measured with the LSFG-NAVI device from Nidek will be investigated. A high reproducibility is crucial for the clinical value of any measuring device.
943 studies on the registry are indexed under Glaucoma, Open-Angle; 118 are open to participants now.
This study's enrollment of 44 is below the median of 100 across 185 observational studies indexed under Glaucoma, Open-Angle.
Browse Glaucoma, Open-Angle studies →University of Zurich is the lead sponsor of 1,048 studies on the registry; 132 are open to participants now.
Counted across the registry records on this site, refreshed daily.
3 groups as described above will be recruted from the outpatient department of the Ophthalmology Department at the UniversityHospital Zurich, Zurich, Switzerland and the Ophthalmology Department at the Cantonal Hospital Aarau, Aarau, Switzerland
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
patients with a diagnosis of open-angle glaucoma, i.e. untreated IOP \>21mmHg plus glaucomatous disc changes and/or visual field defects typical for glaucoma
Diagnostic Test: LASER SPECKLE FLOWGRAPHY
patients with a diagnosis of normal tension glaucoma, i.e. untreated IOP \</=21mmHg plus glaucomatous disc changes and/or visual field defects typical for glaucoma
Diagnostic Test: LASER SPECKLE FLOWGRAPHY
individuals with normal optic disc and IOP \</21mmHg and normal visual fields
Diagnostic Test: LASER SPECKLE FLOWGRAPHY
Non-invasive, real-time imaging and measurement of ocular blood flow of the optic disc and peripapillary region
Coefficients of variation (COV)
COVs from 3 measurements of ocular blood flow at visit 1 of observer 1 and at visit 1 of observer 1 and from observer 2 will be computed.
Time frame: 1 month
intraclass correlation coefficients (ICCs)
Intraobserver ICC, interobserver ICC, and inter-session ICC will be computed
Time frame: 1 month
Cofounder
Blood pressure will be checked as potential cofounder
Time frame: 1 month
Cofounder
heart rate will be checked as potential cofounder
Time frame: 1 month
Cofounder
spherical equivalent will be checked as potential cofounder
Time frame: 1 month
Cofounder
intraocular pressure will be checked as potential cofounder
Time frame: 1 month
Plan to share: No
No publications or documents are linked to this record.
Ran from Jul 2019 to primary completion in Feb 2021, 19 months.
Of 56 observational studies under Glaucoma, Open-Angle, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 12. This study's 19 months is below that.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jun 2023. You cannot join it, but the record below documents what was studied.
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