An observational study in Postpartum Hemorrhage, Treatment Outcome and Pregnancy Outcome, sponsored by University of Zurich. Recruiting at 1 site in Switzerland. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-21.
Sponsored by University of Zurich · Observational
This study will investigate all women treated with vacuum-induced tamponade (VIT) for PPH at a tertiary center, namely at the University Hospital Zurich (USZ), over a nine-year period (2017-2025). By combining hospital data with follow-up patient questionnaires, it will provide new information on reproductive outcomes and contribute to the evaluation of the long-term safety profile of vacuum-induced tamponade.
Postpartum hemorrhage (PPH) is the leading cause of maternal morbidity and mortality worldwide. When first-line medical treatments fail, uterine tamponade is an established second-line intervention. Vacuum-induced tamponade is a relatively new method that offers rapid uterine collapse and bleeding control, and has shown good short-term effectiveness.
Long-term outcomes following vacuum-induced tamponade have not been studied. Specifically, to our knowledge no data exists on its impact on fertility, subsequent pregnancies, or potential complications such as intrauterine adhesions.
Since most women affected by PPH are of reproductive age, this information is highly relevant for clinical care and patient counseling for the following family plan.
This study will investigate all women treated with vacuum-induced tamponade (VIT) for PPH at a tertiary center, namely at the University Hospital Zurich (USZ), over a nine-year period. By combining hospital data with follow-up patient questionnaires, it will provide new information on reproductive outcomes and contribute to the evaluation of the long-term safety profile of vacuum-induced tamponade.
The results may help to guide future clinical decisions, improve patient information, and contribute to the broader evaluation of long-term effects of vacuum-induced tamponade in obstetric practice.
The objective of this project is to descriptively assess the occurrence of secondary infertility in women who underwent vacuum-induced tamponade for postpartum hemorrhage at the University Hospital of Zurich between January 2017 until December 2025.
As long-term reproductive outcomes after VIT have not previously been systematically investigated, this study is primarily exploratory and hypothesis-generating.
The findings will provide preliminary estimates of fertility-related outcomes, including secondary infertility and time to conception, and will serve as a basis for the design, sample size calculation, and feasibility assessment of future prospective studies.
456 studies on the registry are indexed under Postpartum Hemorrhage; 77 are open to participants now.
This study's planned enrollment of 380 is above the median of 169 across 94 observational studies indexed under Postpartum Hemorrhage.
Browse Postpartum Hemorrhage studies →University of Zurich is the lead sponsor of 1,048 studies on the registry; 131 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Women who gave birth between January 2017 and December 2025
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Occurrence of secondary infertility
The primary objective of this project is to descriptively assess the occurrence of secondary infertility in women who underwent vacuum-induced tamponade for postpartum hemorrhage at the University Hospital of Zurich.
Time frame: January 2017 until December 2025
Pregnancy outcomes
Pregnancy outcomes, including pregnancy complications and live birth rates
Time frame: January 2017 until December 2025
Time to conception
Time to conception for * the index pregnancy (i.e. the pregnancy during which VIT was applied), and * the first subsequent pregnancy after VIT
Time frame: January 2017 until December 2025
Patient-reported fertility difficulties
Patient-reported fertility difficulties, including duration of attempts to conceive and the need for assisted reproductive technologies
Time frame: January 2017 until December 2025
Fertility-related complications
Fertility-related complications, such as intrauterine adhesions
Time frame: January 2017 until December 2025
Psychological outcomes
Psychological outcomes before and after childbirth in women with VIT, including the type of reported psychological problems and the use of medication for mental health conditions.
Time frame: January 2017 until December 2025
Plan to share: Undecided
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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