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Enrolling by invitationNCT01630785nphysdocuUpdated Oct 26, 2026

Neurophysiological Intraoperative or Epilepsy Monitoring

An observational study in Patients Operated on at the Neurosurgery Department, sponsored by University of Zurich. Enrolling by invitation at 1 site in Switzerland. Open to participants aged 0 Years to 100 Years. Per ClinicalTrials.gov, last updated 2026-10-26.

Sponsored by University of Zurich · Observational

Updated Oct 26, 2026Now Enrolling by invitationPrimary completion moved+2 moreGo to Updates ↓
Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
10,000
Ages
0 Years to 100 Years
Sex
All
01

Study summary

The investigators record the outcome of patients whose surgery involved intraoperative neurophysiological monitoring

  • Trial with surgical intervention
02

Conditions studied

  • Patients Operated on at the Neurosurgery Department
03

In context

Lead sponsor

University of Zurich is the lead sponsor of 1,048 studies on the registry; 132 are open to participants now.

Browse University of Zurich studies →

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
0 Years to 100 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

All patients whose surgery involved intraoperative neurophysiological monitoring

Eligibility criteria

Inclusion criteria: Patients whose surgery involved intraoperative neurophysiological monitoring

05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
10,000 participants (estimated)
Target follow-up
10 Years
Patient registry
Yes

Groups and cohorts

  • IONM patients

    all patients where surgery requires IONM

    Device: Intraoperative Neurophysiological Monitoring IONM

Interventions

  • DeviceIntraoperative Neurophysiological Monitoring IONM

    Intraoperative Neurophysiological Monitoring IONM device. Manufacturer: Inomed, Emmendingen, Germany

06

What researchers measure

Primary outcomes

  1. oncological outcome

    overall survival, progression free survival

    Time frame: 5 years

  2. neurological outcome

    validated scales like Karnofsky or NIHSS

    Time frame: 1 year

  3. seizure outcome

    ILAE classification of epilepsy surgery outcome

    Time frame: 1 year

07

Study locations

1 site
  • University Hospital Zurich, Neurosurgery
    Zurich, Canton of Zurich 8091, Switzerland
08

References and documents

Publications

  • Yang Y, Neidert MC, Velz J, Kalin V, Sarnthein J, Regli L, Bozinov O. Mapping and Monitoring of the Corticospinal Tract by Direct Brainstem Stimulation. Neurosurgery. 2022 Sep 1;91(3):496-504. doi: 10.1227/neu.0000000000002065. Epub 2022 Jul 14. PubMed 35876678 ↗
09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedDate before it movedWhere the date was before it moved

Started Jan 2012 (actual). Primary completion is estimated for Dec 2035, 287 months after the start.

Since we started tracking on Sep 25, 2026, the dates moved once, on Oct 26, 2026: primary completion Dec 2025 → Dec 2035 and completion Dec 2025 → Dec 2035.

Earlier changes are on the record history on ClinicalTrials.gov ↗

How these figures are worked out, and which studies are left out of them.

Registered
Jun 21, 2012
First posted
Jun 28, 2012
StartActual
Jan 2012
Primary completionEst.
Dec 2035was Dec 2025
CompletionEst.
Dec 2035was Dec 2025
Last update
Oct 26, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Status
Status unknown→Enrolling by invitation
changed Oct 26, 2026
Primary completion
Dec 2025→Dec 2035
Oct 26, 2026
Study completion
Dec 2025→Dec 2035
Oct 26, 2026
Enrollment
5000→10000
Oct 26, 2026
Show all 1 update
  1. Oct 26, 2026
    Status unknown→Enrolling by invitation
    Primary completion Dec 2025→Dec 2035
    Study completion Dec 2025→Dec 2035
    Enrollment 5000→10000
    + 2 other changes: verification date and design details

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT01630785
Lead sponsor
University of Zurich
Responsible party
Sponsor
First posted
Jun 28, 2012
Start date
Jan 2012
Primary completion
Dec 2035 (estimated)
Completion
Dec 2035 (estimated)
Last update
Oct 26, 2026

Study contacts

Johannes Sarnthein, Prof Dr
principal investigator · University Hospital Zurich, Division of Neurosurgery
Oliver Bozinov, PD Dr
principal investigator · University Hospital Zurich, Division of Neurosurgery
Niklaus Krayenbühl, Prof Dr
principal investigator · University Hospital Zurich, Division of Neurosurgery
Luca Regli, Prof Dr
principal investigator · University Hospital Zurich, Division of Neurosurgery
View the source record on ClinicalTrials.gov ↗

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