An interventional study of No intervention and Fan in Coronary Artery Disease, sponsored by Montreal Heart Institute. Completed at 1 site in Canada. Open to participants aged 50 Years to 80 Years. Per ClinicalTrials.gov, last updated 2023-08-01.
Sponsored by Montreal Heart Institute · Not applicable, Interventional, and Basic science
The purpose of this study is to determine the optimal cooling strategies to alleviate cardiovascular strain of coronary artery disease individuals during a simulated North American and Australian heatwave.
Globally, heatwaves are occurring more frequently, are of greater intensity and longer in duration. The devastating health impacts of extreme heat are increasingly recognized, particularly in vulnerable populations, such as adults with coronary artery disease (CAD). While the most effective cooling strategy during a heatwave is the use of air conditioning (AC), economical concerns can limit AC use among vulnerable populations. In addition, widespread AC use places a significant burden on the electrical grid, causing brown-outs and black-outs during periods of extreme heat.
Electric fans offer a cooling strategy with a 50-fold lower power requirement and cost compared to AC. However, the efficacy of fan use during heat waves remains contentious. The primary objective of this study is to identify the optimal cooling strategy to alleviate cardiovascular strain of CAD patients exposed to typical North American heatwave conditions (38°C with 60% relative humidity). The secondary objective is to identify the optimal cooling strategy to alleviate cardiovascular strain of CAD patients exposed to typical Australian heatwave conditions (46°C with 10% relative humidity).
5,598 studies on the registry are indexed under Coronary Artery Disease; 957 are open to participants now.
This study's enrollment of 27 is below the median of 124 across 3,436 interventional studies indexed under Coronary Artery Disease.
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Exclusion Criteria:
The participant will enter an environmental chamber maintained at 38°C and 60% relative humidity. The participant will remain within the environmental chamber and will rest in a seated position for 3 hours.
Other: No intervention
The participant will enter an environmental chamber maintained at 38°C and 60% relative humidity. The participant will remain within the environmental chamber and will rest in a seated position for 3 hours.
Other: Fan
The participant will enter an environmental chamber maintained at 38°C and 60% relative humidity. The participant will remain within the environmental chamber and will rest in a seated position for 3 hours.
Other: Skin Wetting
Tthe participant will enter an environmental chamber maintained at 38°C and 60% relative humidity. The participant will remain within the environmental chamber and will rest in a seated position for 3 hours.
Other: Fan + Skin wetting
The participant will enter an environmental chamber maintained at 46°C and 10% relative humidity.
Other: No intervention
The participant will enter an environmental chamber maintained at 46°C and 10% relative humidity. The participant will remain within the environmental chamber and will rest in a seated position for 3 hours.
Other: Skin Wetting
The participant will rest in a seated position.
A fan placed in front of the participant will provide an airflow of 4 m/s throughout the exposure.
Tap water (\~18°C) will be applied every 5 minutes to the face, neck, upper and lower arms and upper and lower legs using a spray bottle.
A fan placed in front of the participant will provide an airflow of 4 m/s throughout the exposure. In addition, tap water (\~18°C) will be applied every 5 minutes to the face, neck, upper and lower arms and upper and lower legs using a spray bottle.
Rate pressure product
Rate pressure product, in beats per minute per mmHg
Time frame: Change from baseline to the end of the 3 hour exposure
Body core temperature
In degrees Celcius
Time frame: Change from baseline to the end of the 3 hour exposure
Skin temperature
In degrees Celcius
Time frame: Change from baseline to the end of the 3 hour exposure
Sweat loss
In kilograms
Time frame: Change from baseline to the end of the 3 hour exposure
Local sweat rate
In mg per minute per cm2
Time frame: Measured continously during the 3 hour exposure
Skin blood flow
In arbitrary perfusion units
Time frame: Measured continously during the 3 hour exposure.
Plan to share: No — All individual data will be de-identified and available to the public through publications, media articles and conference presentations
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2023. You cannot join it, but the record below documents what was studied.
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Montreal Heart Institute