An interventional study of MRI and PET in Alzheimer Dementia, Posttraumatic Stress Disorder and Traumatic Brain Injury, sponsored by Duke University. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-10-16.
Sponsored by Duke University · Not applicable, Interventional, and Basic science
The purpose of this study is to learn about how trauma, posttraumatic stress disorder (PTSD), and mild traumatic brain injury that can occur during deployment affect the brain. The investigators also want to learn how PTSD and mild traumatic brain injury can affect the chance of developing Alzheimer disease later in life. The investigators will study this by using magnetic resonance imaging and positron emission tomography scans to obtain pictures of the brain.
2,172 studies on the registry are indexed under Dementia; 541 are open to participants now.
Browse Dementia studies →Duke University is the lead sponsor of 2,025 studies on the registry; 275 are open to participants now.
Of its 194 completed or terminated interventional studies of FDA-regulated products, 159 (82%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Volunteers with no trauma history
Device: MRI · Device: PET · Device: 18F-Florbetapir · Device: Radioligand 18F-AV-1451
Volunteers that do not have PTSD but have had similar trauma to those with PTSD
Device: MRI · Device: PET · Device: 18F-Florbetapir · Device: Radioligand 18F-AV-1451
Volunteers with PTSD but no traumatic brain injury
Device: MRI · Device: PET · Device: 18F-Florbetapir · Device: Radioligand 18F-AV-1451
Volunteers with PTSD and mild traumatic brain injury
Device: MRI · Device: PET · Device: 18F-Florbetapir · Device: Radioligand 18F-AV-1451
You will be asked to undergo a scan of your brain called an MRI. The MRI scan can measure the functioning of your brain.
You will be asked to undergo a scan of brain called a positron emission tomography (PET) scan. The PET scan is a test that uses radioactive glucose (sugar) and a computer to create images of how your brain is functioning. Abnormal cells in the body use glucose at a different rate than normal cells and this allows the scanner to create a detailed picture of how your body is working.
At the Duke University PET Center you will be in a quiet dimly lit space with only ambient room sound, with your eyes open and ears unplugged. Your safety will be monitored by a physician and nurse. 18F-florbetapir will be administered to you as a bolus injection through a peripheral vein followed by a flush and 10 minute continuous brain PET imaging will begin 50 minutes post-injection.
Also known as: PET tracer for Amyloid-beta
At the Duke University PET Center you will be in a quiet dimly lit space with only ambient room sound, with your eyes open and ears unplugged. Your safety will be monitored by a physician and nurse. 18F-florbetapir will be administered to you as a bolus injection through a peripheral vein followed by a flush and 10 minute continuous brain PET imaging will begin 50 minutes post-injection.
Also known as: PET tracer for Tau protein
Cortical thickness as measured by MRI scans
Time frame: Baseline
Beta amyloid plaques as measured by PET scans
Time frame: Baseline
Tau proteins as measured by PET scans
Time frame: Baseline
Plan to share: No
No publications or documents are linked to this record.
This study is withdrawn, as verified in Oct 2018. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Duke University