An interventional study of Oxygen Prebreathe and Hypobaric Exposure in Decompression Sickness, sponsored by Duke University. Recruiting at 1 site in United States. Open to participants aged 30 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-05.
Sponsored by Duke University · Not applicable, Interventional, and Prevention
This study evaluates oxygen prebreathe protocols and exercise conditions to reduce risk of decompression sickness during simulated extravehicular activity. Healthy adult volunteers will undergo oxygen prebreathe followed by hypobaric chamber exposure with monitoring for symptoms and ultrasound detection of bubbles.
21 studies on the registry are indexed under Decompression Sickness; 6 are open to participants now.
Browse Decompression Sickness studies →Duke University is the lead sponsor of 2,063 studies on the registry; 273 are open to participants now.
Of its 204 completed or terminated interventional studies of FDA-regulated products, 167 (82%) have results posted.
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Exclusion Criteria:
Participants undergo oxygen prebreathe followed by hypobaric chamber exposure with exercise and monitoring.
Procedure: Oxygen Prebreathe and Hypobaric Exposure
Prebreathe 100% oxygen followed by simulated spacewalk conditions in hypobaric chamber with exercise protocols.
Number of participants with Decompression Sickness
Decompression sickness will be recorded during Extravehicular Activity (EVA) simulation at 6.2 psia following a one-hour oxygen prebreathe while resting, performing light exercise or heavier exercise.
Time frame: Up to 6 months
Plan to share: No
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