An observational study in Chronic Periodontitis and Occlusal Trauma, sponsored by Tokat Gaziosmanpasa University. Completed at 2 sites in Turkey. Open to participants aged 29 Years to 42 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-08-10.
Sponsored by Tokat Gaziosmanpasa University · Observational
Present study suggests that excessive occlusal forces did not cause a significant change in hypoxia and vascular markers, however a slight alteration in subgingival microbiota was observed.
Occlusal trauma is defined as tissue destruction and/or injury resulting in tissue changes in the periodontium as a consequence of excessive occlusal forces or hyper-occlusion. Previous studies suggested accelerated periodontal destruction around teeth with occlusal trauma and increased mobility, however, the evidence is lacking. Recent animal studies found that occlusal trauma increased osteoclastic activity and alveolar bone loss. One possible mechanism suggested for the progression of periodontal destruction with occlusal trauma is that tooth mobility creates a subgingival environment conducive to overgrowth by periodontal pathogens. However, the association of occlusal trauma and subgingival microbiota was not evaluated in previous studies. Therefore, present study aimed to evaluate subgingival dental plaque components and compare with healthy individuals and periodontitis patients without occlusal trauma.
1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.
This study's enrollment of 80 is below the median of 90 across 428 observational studies indexed under Periodontitis.
Browse Periodontitis studies →Tokat Gaziosmanpasa University is the lead sponsor of 164 studies on the registry; 38 are open to participants now.
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The study population consisted of 80 participants and 4 study groups were created as follows:
Group 1; healthy individuals without occlusal trauma (Group 1, n=20), 6 men and 14 women, mean age 32.06±2.90 Group 2; periodontitis patients without occlusal trauma (Group 2, n=20), 6 men and 14 women, mean age 36.90±4.67 Group 3; healthy individuals with occlusal trauma (Group 3, n=20), 5 men and 15 women, mean age 34.89±7.51 Group 4; periodontitis patients with occlusal trauma (Group 4, n=20) 7 men and 13 women, mean age 36.76±4.40.
Exclusion Criteria:
Orally and systemically healthy individuals who has no hypo-functional teeth, hyper-occlusion or occlusal trauma
Systemically healthy individuals who has chronic periodontitis but no hypo-functional teeth, hyper-occlusion or occlusal trauma
Orally and systemically healthy individuals who has occlusal trauma caused by bruxism
Systemically healthy individuals who has both chronic periodontitis and occlusal trauma caused by bruxism
Determination of certain bacterial species in subgingival dental plaque
Subgingival dental plaque samples were collected from each participant and evaluated via polymerase-chain reaction.
Time frame: A day after initial examination
hypoxic changes in gingiva and serum
Determination of the hypoxia inducible factor-alpha and vascular endothelial growth factor via ELISA
Time frame: One day after initial examination
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Aug 2018. You cannot join it, but the record below documents what was studied.
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Tokat Gaziosmanpasa University