An interventional study of traditional speed and faster speed in Fluid Loss, sponsored by Qingdao University. Status unknown at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-08-28.
Sponsored by Qingdao University · Not applicable, Interventional, and Treatment
Previous studies have shown that a positive fluid balance was an independent factor of worse prognosis in ICU patients with acute respiratory distress syndrome (ARDS), and negative fluid balance has been demonstrated to increase oxygenation index, reduce time under mechanical ventilation and ICU length of stay with no noticeable adverse effects. But there is no evidence that faster speed of negative fluid balance would be more beneficial for ARDS patients. So researchers designed the study to prove the effect of negatively fluid balancing speed for ICU patients with ARDS.
1,597 studies on the registry are indexed under Respiratory Distress Syndrome; 312 are open to participants now.
This study's planned enrollment of 70 is above the median of 60 across 961 interventional studies indexed under Respiratory Distress Syndrome.
Browse Respiratory Distress Syndrome studies →Qingdao University is the lead sponsor of 22 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
·Patients with ARDS (Berlin 2012 criterion）
Exclusion Criteria:
The target amount of every day's net negative fluid balance for the first three days is 1000mL.
Other: traditional speed
The target amount of every day's net negative fluid balance for the first three days is 1500mL.
Other: faster speed
ARDS patients are performed negative fluid balance strategy with intravenous furosemide (4mg/h) or continuous veno-venous hemofiltration. The target amount of every day's net negative fluid balance for the first three days is 1000mL.Termination of the strategy is performed when mean arterial pressure drops below 65mmHg or perfusion index drops below 0.82 or lactate increases above 2mmol/L or acute kidney injury occurs.
ARDS patients are performed negative fluid balance strategy with intravenous furosemide (4mg/h) or continuous veno-venous hemofiltration. The target amount of every day's net negative fluid balance for the first three days is 1500mL.Termination of the strategy is performed when mean arterial pressure drops below 65mmHg or perfusion index drops below 0.82 or lactate increases above 2mmol/L or acute kidney injury occurs.
increased oxygenation index proportion at 24h
Oxygenation index equals arterial oxygen partial pressure/fraction of inspiration O2 (PO2/FIO2). Increased oxygenation index proportion at 24h equals (oxygenation index at 24h - oxygenation index at baseline)/ oxygenation index at baseline.
Time frame: at the time of 24 hours
Oxygenation index every day
oxygenation index equals arterial oxygen partial pressure/fraction of inspiration O2 (PO2/FIO2).
Time frame: up to 7 days
Duration of free mechanical ventilation
Days when patients are free of mechanical ventilation
Time frame: up to 28 days
mortality
a measure for the rate at which deaths occur in a given population
Time frame: up to 28 days
Plan to share: Undecided
This study is status unknown, as verified in Aug 2019. You cannot join it, but the record below documents what was studied.
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Respiratory Distress Syndrome→
Qingdao University