An observational study in Feeding Patterns, Critical Illness and Circadian Rhythm Disorders, sponsored by Qingdao University. Recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2023-10-17.
Sponsored by Qingdao University · Observational
Circadian rhythms plays an important role for healthy. And critical illness contributes to the disruption of circadian rhythms. Not only right but also feeding can affect the circadian clock gene expression. In a investigators' previous study, some metabolic indicators (the albumin level, total cholesterol level and total bile acid level) and the increases in lymphocyte counts in the sequential feeding group were different from those in the continuous feeding group. Investigators think sequential feeding may adjust circadian clock gene expression for its effect on metabolism and immunity. Moreover, sequential feeding did alter the abundances of some gut microbes to some degree in the investigators' previous study. Investigators think sequential feeding may adjust gut flora rhythms.
985 studies on the registry are indexed under Feeding Behavior; 178 are open to participants now.
This study's planned enrollment of 20 is below the median of 183 across 270 observational studies indexed under Feeding Behavior.
Browse Feeding Behavior studies →Qingdao University is the lead sponsor of 22 studies on the registry; 4 are open to participants now.
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ICU patients
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Exclusion Criteria:
After achieving ≥80% of the nutrition target calories (25-30 kcal/kg/d) by continuous feeding, continuous feeding was changed into intermittent feeding. The total daily dosage of enteral nutrition was equally distributed during three periods at 7-9:00, 11-13:00 and 17-19:00. The enteral nutritional suspension administered during each period was given at a uniform rate within two hours by an enteral feeding pump. The other times of the day were fasting times.
Other: feeding type
Patients received continous feeding with a constant velocity by an enteral feeding pump over one day.
Other: feeding type
In our department, the ICU patients received continuous feeding or sequential feeding. Patients received continuous feeding with a constant velocity by an enteral feeding pump over one day. In sequential feeding type, after achieving ≥80% of the nutrition target calories (25-30 kcal/kg/d), the patients received intermittent feeding. The total daily dosage of enteral nutrition was equally distributed during three periods at 7-9:00, 11-13:00 and 17-19:00. The enteral nutritional suspension administered during each period was given at a uniform rate within two hours by an enteral feeding pump. The other times of the day were fasting times.
clock genes expression
Genes including BMAL1 CLOCK TIMELESS PER1 and so on
Time frame: 7 days feeding
Gut Flora Rhythm
α diversity including shannon index and so on
Time frame: 7 days feeding
Plan to share: Undecided
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Qingdao University