Change of Lung Function After Exercise in Patients With Chronic Obstructive Pulmonary Disease

Browse trials for

• Lung Diseases 3,303
• Lung Diseases, Obstructive 2,592
• Pulmonary Disease, Chronic Obstructive 4,131
• Chronic Disease 990

Keywords

• Pulmonary Disease, Chronic Obstructive
• exercise
• lung function
• quality of life

Lung Diseases

3,303 studies on the registry are indexed under Lung Diseases; 355 are open to participants now.

This study's planned enrollment of 50 is below the median of 72 across 2,118 interventional studies indexed under Lung Diseases.

Lead sponsor

Zhujiang Hospital is the lead sponsor of 199 studies on the registry; 96 are open to participants now.

Study arms

• Experimental
  Budesonide and formoterol bid

  At baseline,lung function test,blood oxygen saturation and pulse are measured before and after 6-min walk test for each subject.Quality of life is assessed through questionnaires including modified Medical Research Council dyspnoea scale(mMRC),St George's Respiratory Questionnaire(SGRQ),clinical chronic obstructive pulmonary questionnaire(CCQ) and chronic obstructive pulmonary disease assessment test(CAT).And then budesonide(160ug) and formoterol(4.5ug) bid will be given to the subjects for 3 months.The subjects will have a follow-up visit with all the examinations mentioned above after 3 months' treatment.

  Drug: Budesonide and formoterol bid

Interventions

• DrugBudesonide and formoterol bid

  At baseline,lung function test,blood oxygen saturation and pulse are measured before and after 6-min walk test for each subject.Quality of life is assessed through questionnaires including modified Medical Research Council dyspnoea scale(mMRC),St George's Respiratory Questionnaire(SGRQ),clinical chronic obstructive pulmonary questionnaire(CCQ) and chronic obstructive pulmonary disease assessment test(CAT).And then budesonide(160ug) and formoterol(4.5ug) bid will be given to the subjects for 3 months.The subjects will have a follow-up visit with all the examinations mentioned above after 3 months' treatment.

  Also known as: SYMBICORT TURBUHALER

Primary outcomes

1. Changes of forced expired volume in one second(FEV1) after 6-min walk test compared with resting state

   Forced expired volume in one second(FEV1) is measured by Jaeger MasterScreen Pulmonary Function Test System before and after 6-min walk test.

   Time frame: At resting state and after 6-min walk test

Secondary outcomes

1. Changes of inspiratory capacity(IC) after 6-min walk test compared with resting state

   Inspiratory capacity(IC) is measured by Jaeger MasterScreen Pulmonary Function Test System before and after 6-min walk test.

   Time frame: At resting state and after 6-min walk test

2. Changes of blood oxygen saturation after 6-min walk test compared with resting state

   Blood oxygen saturation is measured before and after 6-min walk test.

   Time frame: At resting state and after 6-min walk test

3. Changes of pulse after 6-min walk test compared with resting state

   Pulse is measured before and after 6-min walk test.

   Time frame: At resting state and after 6-min walk test

4. Changes of forced expired volume in one second(FEV1) after 3 months' treatment compared with baseline

   At baseline,forced expired volume in one second(FEV1) is measured.After 3 months's treatment of budesonide and formoterol,FEV1 will be measured again.

   Time frame: Change from baseline to 3 months

5. Changes of inspiratory capacity(IC) after 3 months' treatment compared with baseline

   At baseline,inspiratory capacity(IC) is measured.After 3 months's treatment of budesonide and formoterol,IC will be measured again.

   Time frame: Change from baseline to 3 months

6. Changes of diffusion function after 3 months' treatment compared with baseline

   At baseline,diffusion function is measured.After 3 months's treatment of budesonide and formoterol,diffusion function will be measured again.

   Time frame: Change from baseline to 3 months

7. Changes of impulse forced oscillometry parameters after 3 months' treatment compared with baseline

   At baseline,impulse forced oscillometry parameters are measured.After 3 months's treatment of budesonide and formoterol,impulse forced oscillometry parameters will be measured again.

   Time frame: Change from baseline to 3 months

8. Changes of modified Medical Research Council dyspnoea scale(mMRC) scores after 3 months' treatment compared with baseline

   At baseline,quality of life is assessed by modified Medical Research Council dyspnoea scale(mMRC).After 3 months's treatment of budesonide and formoterol,the mMRC scores will be measured again.

   Time frame: Change from baseline to 3 months

9. Changes of St George's Respiratory Questionnaire(SGRQ) scores after 3 months' treatment compared with baseline

   At baseline,quality of life is assessed by St George's Respiratory Questionnaire(SGRQ).After 3 months's treatment of budesonide and formoterol,the SGRQ scores will be measured again.

   Time frame: Change from baseline to 3 months

10. Changes of clinical chronic obstructive pulmonary questionnaire(CCQ) scores after 3 months' treatment compared with baseline

    At baseline,quality of life is assessed by clinical chronic obstructive pulmonary disease questionnaire(CCQ).After 3 months's treatment of budesonide and formoterol,the scores will be measured again.

    Time frame: Change from baseline to 3 months

11. Changes of chronic obstructive pulmonary disease assessment test(CAT) scores after 3 months' treatment compared with baseline

    At baseline,quality of life is assessed by chronic obstructive pulmonary disease assessment test(CAT).After 3 months's treatment of budesonide and formoterol,the test will be performed again.

    Time frame: Change from baseline to 3 months

12. The distance and steps of 6-min walk test

    Both the the distance and steps are measured

    Time frame: Change from baseline to 3 months