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CompletedNCT03494309Updated Apr 11, 2018

Open Versus Closed Reduction of Mandibular Sub-Condylar Fractures

An interventional study of Open Reduction & Internal Fixation and Closed Reduction & External Fixation in Mandibular Fractures, sponsored by King Edward Medical University. Completed. Open to participants aged 16 Years to 60 Years. Per ClinicalTrials.gov, last updated 2018-04-11.

Sponsored by King Edward Medical University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
70
Allocation
Randomized
Ages
16 Years to 60 Years
Sex
All
01

Study summary

Patients with mandibular sub-condylar fractures underwent either either open reduction with internal fixation (ORIF) or closed reduction with external fixation (CREF) and were followed up for 6 months to assess treatment adequacy with the hypothesis that ORIF is superior to CREF.

02

Conditions studied

  • Mandibular Fractures

Keywords

  • Mandibular Subcondylar Fractures
  • Mouth Opening
  • Open Reduction and Internal Fixation
  • Closed Reduction with External Fixation
03

Who can participate

Ages eligible
16 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Age 16-60 years
  • Displaced Mandibular Subcondylar Fractures(MCFs) irrespective of multiple mandibular fractures.

Exclusion criteria

Exclusion Criteria:

  • Bilateral MCFs
  • MCF with mid-facial fractures
  • Insufficient bilateral dentition
  • Medically unfit for surgery
  • Old healed mandibular fractures
  • History of previous mandibular surgery for the same indication
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
70 participants (actual)

Study arms

  • Experimental
    ORIF

    Open Reduction \& Internal Fixation

    Procedure: Open Reduction & Internal Fixation

  • Active comparator
    CREF

    Closed Reduction \& External Fixation

    Procedure: Closed Reduction & External Fixation

Interventions

  • ProcedureOpen Reduction & Internal Fixation

    Patients underwent surgery and the fractures were reduced under direct vision followed by internal fixation with titanium plates and screws

  • ProcedureClosed Reduction & External Fixation

    Patients underwent closed reduction of the fracture and external fixation by arch bars \& guided elastics

05

What researchers measure

Primary outcomes

  1. Mouth Opening

    Mouth Opening shall be determined by measuring the maximal distance between the edges of upper and lower incisors with fully opened mouth; the measurement shall be made in millimeters (mm) using vernier caliper and mouth opening of 35 mm or more shall be classified as "adequate"

    Time frame: 6 months

  2. Occlusion

    Occlusion shall be determined by maximum "inter-cuspation" as observed by the surgeon and patient self-reporting and will be classified as fine or deranged.

    Time frame: 6 months

Secondary outcomes

  1. Complications

    The frequency of complications with either mode of treatment shall be recorded

    Time frame: 6 months

  2. Cost-Effectiveness

    Cost-Effectiveness shall be determined as the ratio of the cost of treatment and achievement of both adequate mouth opening and fine occlusion. The cost of treatment shall include the cost of surgical items (wires, elastics, arch bars, plates, screws etc), cost of anesthesia and surgery, cost of hospital stay and cost of follow up.

    Time frame: 6 months

  3. Patient Satisfaction

    Participants shall be requested to report their satisfaction after treatment with regards to ease of chewing, mouth opening \& closing and achievement of pre0traumatic facial symmetry/orientation. This parameter shall be recorded on a 4-point Likert scale (not satisfied, somewhat dissatisfied, somewhat satisfied, satisfied).

    Time frame: 6 months

06

Study locations

No study locations are listed for this record.

07

Registry details

Key details

Study ID
NCT03494309
Lead sponsor
King Edward Medical University
Responsible party
Samira S Baloch (Assistant Professor of Oral & Maxillofacial Surgery, King Edward Medical University) — Principal investigator
First posted
Apr 11, 2018
Start date
Nov 1, 2014
Primary completion
Nov 15, 2015
Completion
Nov 15, 2015
Last update
Apr 11, 2018

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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