An interventional study of Aerogen Solo® and Heated-humidified circuit in Brain Injuries, Traumatic, sponsored by Cliniques universitaires Saint-Luc- Université Catholique de Louvain. Completed at 1 site in Belgium. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-11-04.
Sponsored by Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Not applicable, Interventional, and Supportive care
The intention is to enroll a specific sample of intubated patients. To compare the effect of respiratory gas conditioning on lung deposition and considering the well-known influences of lung pathology on lung deposition, intubated patients with healthy lungs will be included. Postoperative neurosurgery ventilated patients respond perfectly to this criteria. A previous study including 17 postoperative neurosurgery patients was performed in 2013 with a perfect collaboration between the ICU and the Department of Neurosurgery and Anesthesiology.
Exclusion Criteria:
Device: Aerogen Solo® · Device: Heated-humidified circuit
Device: Aerogen Solo® · Device: Heated-humidified circuit
Device: Aerogen Solo® · Device: Conventional dry ventilator circuit with HME filter
Device: Aerogen Solo® · Device: Dry ventilator circuit specific for aerosol therapy
Aerosol particles are generated by a vibrating-mesh nebulizer specifically designed for mechanical ventilation
It will be left on during the transfer and the nebulization in group 1
It will be turned off 30 minutes before the nebulization (nebulization ended max 45 minutes after turning off the heated-humidifier).
Streamlined components, specific position for the nebulizer at 30 cm of a V-shaped Y piece
The nebulizer is placed between the filter and the endotracheal tube.
Quantity of aerosol deposition from the nebulizer reservoir to the subject. Measured by Planar scintigraphy.
% of the nominal dose.
Time frame: 45 minutes
This study is completed, as verified in Nov 2022. You cannot join it, but the record below documents what was studied.
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Cliniques universitaires Saint-Luc- Université Catholique de Louvain