An interventional study of Magstim rTMS in Aphasia, Primary Progressive and Repetitive Transcranical Magnetic Stimulation, sponsored by Peking Union Medical College Hospital. Withdrawn. Open to participants aged 35 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-06-05.
Sponsored by Peking Union Medical College Hospital · Not applicable, Interventional, and Treatment
The primary progressive aphasia (PPA) is a neurodegenerative condition characterized by a gradual, irreversible decline of language function (Mesulam, 2001). There are no known treatments for PPA so far. The relentless progression of PPA symptoms eventually leads to a profound impairment in communication ability and, ultimately, to more generalized deficits of cognition. Some cases and small studies reported that Transcranial Magnetic Stimulation (TMS), one of the non-invasive neuromodulation tech, can be employed to facilitate language production and improve the language ability in patients with PPA. Herein we will explore the tolerance and efficacy of TMS for the treatment of PPA by the randomized controlled trial .Meanwhile the functional MRI tech will be used to investigate the neural network changing in the procedure
All participants had also been evaluated previously by a behavioral neurologist at the Peking Union Medical College Hospital and had been clinically diagnosed with a variant of PPA.
Exclusion Criteria:
The participants will be devided into rTMS treatment and sham treatment by means of randomized methods.The protocol of treatment is to use rTMS with high frequency 10/20Hz 120%RMT 20 times for one month. The device is Magtism rTMS made in London, UK
Device: Magstim rTMS
The control group is to receive sham treatment. The device is the same as the one used in the real treatment group.
Device: Magstim rTMS
The device is made in London,UK
Boston naming test evaluation
Assessment of the language production
Time frame: Baseline
Boston naming test evaluation
Assessment of the language production
Time frame: One month(just after 20 times rTMS treatment)
Western Aphasia Battery(WAB) Speech fluency
Assessment of the language production
Time frame: Baseline
Western Aphasia Battery(WAB) Speech fluency
Assessment of the language production
Time frame: One month(just after 20 times rTMS treatment)
Repetition Part of WAB
Assessment of the repetition ability
Time frame: Baseline
Repetition Part of WAB
Assessment of the repetition ability
Time frame: One month(just after 20 times rTMS treatment)
Word recognition Part of WAB
Assessment of the reading
Time frame: Baseline
Word recognition Part of WAB
Assessment of the reading
Time frame: One month(just after 20 times rTMS treatment)
Syntax comprehension Part of Bilingual Aphasia Battery( Standard modern Chinese version)
Assessment of the grammar ability
Time frame: Baseline
Syntax comprehension Part of Bilingual Aphasia Battery( Standard modern Chinese version)
Assessment of the grammar ability
Time frame: One month(just after 20 times rTMS treatment)
fMRI parameters(strength, efficiency, clustering coefficient, and characteristic path length)
Graph theoretical analysis of the speech/language network
Time frame: Baseline
fMRI parameters(strength, efficiency, clustering coefficient, and characteristic path length)
Graph theoretical analysis of the speech/language network
Time frame: One month(just after 20 times rTMS treatment)
No study locations are listed for this record.
This study is withdrawn, as verified in Jun 2020. You cannot join it, but the record below documents what was studied.
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Peking Union Medical College Hospital