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RecruitingNCT06323629Updated Sep 14, 2026

Effects of Recursive Self-feedback on Speech Production in Aphasia

An interventional study of Adaptive recursive self-feedback procedure and Non-adaptive recursive self-feedback procedure in Aphasia and Stroke, sponsored by University of South Florida. Recruiting at 1 site in United States. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-09-14.

Sponsored by University of South Florida · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Started Aug 2024; still recruiting 2 years 2 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
45
Allocation
Randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

The goal of this clinical trial is to test the effects of recursive self-feedback procedures on spontaneous speech production in stroke survivors with impaired speech production (aphasia). The main question it aims to answer is:

  • To what extent can stroke survivors with aphasia use their self-feedback alone to improve their spontaneous speech production?

Participants will be engaged in the following activities:

  • They will perform language and cognitive tasks.
  • Afterwards, they will receive treatments using tablets and headphones at no cost to them.
  • The experimental treatments (recursive self-feedback procedures) entails responding to prompts, listening to playbacks of their speech response and attempt to minimize/correct the errors in the next attempt. This process will be repeated multiple times per prompt.
  • The experimental treatments are two: an adaptive version that adapts the complexity of the treatment prompt and a non-adaptive version that does not adapt task complexity.
  • Researchers will compare the experimental treatments to see if both have similar effects on improving spontaneous speech production.
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Conditions studied

  • Aphasia
  • Stroke

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03

In context

Aphasia

338 studies on the registry are indexed under Aphasia; 95 are open to participants now.

This study's planned enrollment of 45 is above the median of 30 across 298 interventional studies indexed under Aphasia.

Browse Aphasia studies →

Lead sponsor

University of South Florida is the lead sponsor of 340 studies on the registry; 65 are open to participants now.

Of its 17 completed or terminated interventional studies of FDA-regulated products, 4 (24%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • 6 months post left hemisphere stroke
  • Aphasia due to left hemisphere stroke
  • Dominant English speaker

Exclusion criteria

Exclusion Criteria:

  • Speech-language deficits due to neurological insults such as Parkinson's disease, neurodegenerative conditions etc.
  • Uncorrected sensory impairments.
  • Language comprehension impairment.
  • Severe cognitive impairment.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
45 participants (estimated)

Study arms

  • Experimental
    Adaptive recursive self-feedback procedure

    Using a tablet, participants listen to speech playback of their response to a prompt and self-correct/minimize their speech errors in a subsequent attempt. This process is looped multiple times per prompt. It adapts across narrative prompts with low and high complexities.

    Behavioral: Adaptive recursive self-feedback procedure

  • Experimental
    Non-adaptive recursive self-feedback procedure

    Using a tablet, participants listen to speech playback of their response to a prompt and self-correct/minimize their speech errors in a subsequent attempt. This process is looped multiple times per prompt. However, it only uses narrative prompts with high complexity.

    Behavioral: Non-adaptive recursive self-feedback procedure

Interventions

  • BehavioralAdaptive recursive self-feedback procedure

    The intervention uses self-feedback alone to improve speech production. It adapts the complexity of the treatment tasks.

  • BehavioralNon-adaptive recursive self-feedback procedure

    The intervention uses self-feedback alone to improve speech production. However, it does not adapt the complexity of the treatment tasks.

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What researchers measure

Primary outcomes

  1. Speaking rate

    Correct words produced per minute

    Time frame: Within 1 week before treatment and within 1 week after treatment.

  2. Speech initiation latency in milliseconds

    Latency before retrieving the first correct word in an utterance.

    Time frame: Within 1 week before treatment and within 1 week after treatment.

07

Study locations

1 of 1 sites recruiting
  • Brain and Aphasia Recovery Lab, PCD 1030, Department of Communication Sciences and Disorders, University of South Florida
    Tampa, Florida 33620, United States
    Recruiting
08

References and documents

Individual participant data

Plan to share: No — Individual participant data will only be shared with approved members of the research team.

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 14, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06323629
Collaborators
Center for Smart Use of Technologies to Assess Real-world Outcomes
Responsible party
Sponsor
First posted
Mar 21, 2024
Start date
Aug 29, 2024
Primary completion
Dec 2027 (estimated)
Completion
Dec 2027 (estimated)
Last update
Sep 14, 2026

Study contacts

Gerald C. Imaezue, PhD
Contact
gimaezue@usf.com
(813)974-2464
William Burgin, MD
Contact
wburgin@usf.edu
813-259-8577
Gerald C. Imaezue, PhD
principal investigator · University of South Florida

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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