CClinicalTrials.gg
CompletedNCT03430141NWHSUpdated Sep 22, 2020

A Nutritarian Study to Evaluate the Effectiveness of Lifestyle Changes in Chronic Disease Prevention, Especially Cancer

An interventional study of Nutritarian Diet-style in Chronic Disease, Cancer and Cardiovascular Diseases, sponsored by Northern Arizona University. Completed at 1 site in United States. Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-09-22.

Sponsored by Northern Arizona University · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
2,898
Allocation
Not applicable
Ages
18 Years and older
Sex
Female
01

Study summary

The Nutritarian Women's Health Study (NWHS) is a long-term hybrid effectiveness-implementation study on the effect of the Nutritarian Diet on the occurrence, recurrence, and progression of chronic diseases (including all forms of cancer and cardiometabolic risk factors).

Read the detailed description

The Nutritional Research Foundation, in conjunction with Northern Arizona University, is conducting a long-term health study for women ages 18 and older. This study will address the effects of a nutrient dense, plant-rich diet on the long-term risks of cancer and other chronic diseases.

Participants enroll in a 30-day training module which outlines the benefits of a nutrient-dense, plant-rich diet. At the conclusion of those videos and written modules, they take a short quiz to assess their knowledge and they can enroll in the full study.

All participation is online with ongoing modules on nutrition and lifestyle. There is a comprehensive health history and lifestyle index to be completed. Nutrition questionnaires will be administered an average of every 3-6 months; PHQ-9 (Patient Health Questionnaire) \& PSQI (Pittsburgh Sleep Quality Index) questionnaires an average of every 12 months; serum cardiometabolic measures and liquid biopsies an average of every 18 months.

02

Conditions studied

  • Chronic Disease
  • Cancer
  • Cardiovascular Diseases
  • Diabetes Mellitus
  • Lifestyle-related Condition
  • Mental Health Wellness 1
  • Sleep
  • Nutritional and Metabolic Disease
  • Nutrition Related Cancer
  • Nutritional Imbalance
  • Thyroid
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
Female
Accepts healthy volunteers
Yes

Inclusion criteria

  • Women only
  • Age 18 years and older.
  • Must be willing to complete an online program
  • Follow the dietary guidelines as outlined to the best of their ability.
  • English-speaking
  • US residents
  • Have internet access
  • Pregnant women are eligible

Exclusion criteria

Exclusion criteria:

  • None
04

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
2,898 participants (actual)

Study arms

  • Experimental
    Intervention for all participants

    Nutritarian Diet-style: Intervention for all participants: All participants are exposed to the same nutrition treatment/intervention protocol.

    Other: Nutritarian Diet-style

Interventions

  • OtherNutritarian Diet-style

    Nutritarian Diet-style: Daily consumption of greens, beans/legumes, a variety of other vegetables, fresh or frozen fruits, nuts, seeds and whole grains. Participants are encouraged to minimize consumption of refined grains, vegetable oils, processed foods, and to limit animal products.

05

What researchers measure

Primary outcomes

  1. Nutrition Intervention

    Adherence to the recommended dietary protocol with the Nutritarian Health Indicator (©Joel Furhman MD). Scored by points (90-100 excellent, 80-89 good, 70-79 average, \<69 poor).

    Time frame: Every 12 months, up to 10 years.

Secondary outcomes

  1. Weight Management

    Height/weight/BMI of participants through self-reported measurements. Weight and height will be combined to report BMI in kg/m\^2.

    Time frame: Every 12 months, up to 10 years.

  2. Waist Measurement

    Self-measured and reported measurements in inches.

    Time frame: Every 12 months, up to 10 years.

  3. Hip Measurement

    Self-measured and reported measurements in inches.

    Time frame: Every 12 months, up to 10 years.

  4. Mental Health

    PHQ-9 (Patient Health Questionnaire-9). Tool designed for screening, diagnosing, monitoring and measuring the severity of depression. Scoring: 5-9 (minimal symptoms), 10-14 (minor depression, dysthymia, mild major depression), 15-19 (major depression, moderately severe), and \>20 (major depression, severe).

    Time frame: Every 12 months, up to 10 years.

  5. Sleep quality assessment

    PSQI (Pittsburgh Sleep Quality Index). Tool designed to evaluate sleep quality over a 1 month interval. Scoring 0-21 points. Any score \>5 indicates sleep impairment, with higher scores designating poorer sleep and greater impact on daily life.

    Time frame: Every 12 months, up to 10 years.

  6. Cancer prevalence

    Self-reported occurrence, recurrence, and progression of cancer at any site. Will be expressed as frequency distribution across the study population.

    Time frame: Every 12 months, up to 10 years.

  7. Chronic disease prevalence

    Self-reported occurrence, recurrence, and progression of chronic disease (diabetes, cardiovascular disease, inflammatory disease). Will be expressed as frequency distribution across the study population.

    Time frame: Every 12 months, up to 10 years.

06

Study locations

1 site
  • Northern Arizona University
    Flagstaff, Arizona 86011, United States
07

References and documents

Publications

  • Sutliffe JT, Fuhrman JH, Carnot MJ, Beetham RM, Peddy MS. Nutrient-dense, Plant-rich Dietary Intervention Effective at Reducing Cardiovascular Disease Risk Factors for Worksites: A Pilot Study. Altern Ther Health Med. 2016 Sep;22(5):32-6. PubMed 27622958 ↗
  • Sarter B. Effect of a high nutrient density diet on long-term weight loss: a retrospective chart review. Altern Ther Health Med. 2011 Nov-Dec;17(6):10; author reply 10. No abstract available. PubMed 22314713 ↗
  • Jenkins DJ, Kendall CW, Faulkner DA, Nguyen T, Kemp T, Marchie A, Wong JM, de Souza R, Emam A, Vidgen E, Trautwein EA, Lapsley KG, Holmes C, Josse RG, Leiter LA, Connelly PW, Singer W. Assessment of the longer-term effects of a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia. Am J Clin Nutr. 2006 Mar;83(3):582-91. doi: 10.1093/ajcn.83.3.582. PubMed 16522904 ↗
  • Yokoyama Y, Barnard ND, Levin SM, Watanabe M. Vegetarian diets and glycemic control in diabetes: a systematic review and meta-analysis. Cardiovasc Diagn Ther. 2014 Oct;4(5):373-82. doi: 10.3978/j.issn.2223-3652.2014.10.04. PubMed 25414824 ↗
  • Sutliffe JT, Wilson LD, de Heer HD, Foster RL, Carnot MJ. C-reactive protein response to a vegan lifestyle intervention. Complement Ther Med. 2015 Feb;23(1):32-7. doi: 10.1016/j.ctim.2014.11.001. Epub 2014 Dec 3. PubMed 25637150 ↗
  • Fuhrman J, Sarter B, Glaser D, Acocella S. Changing perceptions of hunger on a high nutrient density diet. Nutr J. 2010 Nov 7;9:51. doi: 10.1186/1475-2891-9-51. PubMed 21054899 ↗
  • Gonzales JF, Barnard ND, Jenkins DJ, Lanou AJ, Davis B, Saxe G, Levin S. Applying the precautionary principle to nutrition and cancer. J Am Coll Nutr. 2014;33(3):239-46. doi: 10.1080/07315724.2013.866527. Epub 2014 May 28. PubMed 24870117 ↗
  • Tucker KL, Hallfrisch J, Qiao N, Muller D, Andres R, Fleg JL; Baltimore Longitudinal Study of Aging. The combination of high fruit and vegetable and low saturated fat intakes is more protective against mortality in aging men than is either alone: the Baltimore Longitudinal Study of Aging. J Nutr. 2005 Mar;135(3):556-61. doi: 10.1093/jn/135.3.556. PubMed 15735093 ↗

Individual participant data

Plan to share: Yes — We are considering making this data available to other researchers after we have a substantial number of participants enrolled.

Supporting information: Study protocol, Csr

08

Registry details

Key details

Study ID
NCT03430141
Lead sponsor
Northern Arizona University
Responsible party
Jay Sutliffe (Associate Professor, Northern Arizona University) — Principal investigator
First posted
Feb 12, 2018
Start date
Oct 31, 2016
Primary completion
Dec 31, 2019
Completion
Dec 31, 2019
Last update
Sep 22, 2020

Study contacts

Jay Sutliffe
principal investigator · Northern Arizona University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2020. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion