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CompletedNCT03380897Updated Jun 11, 2020

Sleep and Depression in Induction of Labour

An interventional study of Intervention for outpatient group was to go home and Intervention for inpatient group was to stay at ward in Prolonged Pregnancy, Sleep Disturbance and Depression, sponsored by Turku University Hospital. Completed at 1 site in Finland. Open to female participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-06-11.

Sponsored by Turku University Hospital · Not applicable, Interventional, and Health services research

Phase
Not applicable
Study type
Interventional
Enrollment
117
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
Female
01

Study summary

Randomised trial comparing double balloon catheter for induction of labor between inpatient and outpatient groups. The investigators assess how sleep disturbances and depression of the mother affect to the pain during balloon catheter induction of labour.

Read the detailed description

Participants included to this randomised study are women with uncomplicated singleton pregnancy with ≥ 37- ≤ 41+5 weeks of gestation. Participants are randomised to two groups: one hundred are randomised to the inpatient and one hundred to the outpatient group.

The main outcome measure is the pain evaluated by VAS at one, five , nine and 13 hours after the placement of double balloon induction catheter. The investigators assess also the effect of the sleep disturbance and depression of the mother to the pain during balloon catheter induction of the labour.

The total hospital stay and induction to delivery interval time is measured. Also the mode of birth as well as maternal and neonatal morbidity and patient satisfaction are recorded.

02

Conditions studied

  • Prolonged Pregnancy
  • Sleep Disturbance
  • Depression

Keywords

  • induction of labor
  • double balloon catheter
  • mechanical ripening
03

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes

Inclusion criteria

  • uncomplicated pregnancy
  • singleton pregnancy
  • pregnancy weeks ≥ 37 - ≤ 41+5
  • the patient is living in1/2 hour away from hospital

Exclusion criteria

Exclusion Criteria:

  • patient has a disease that is effecting to the pregnancy e.g. pre-eclampsia, gestational hepatosis
  • the patient has medical treatment of diabetes
  • baby is not growing normally
  • multiple pregnancy
  • preterm rupture of membranes
  • earlier caesarean section
  • the patient is living more than 1/2 hour away from hospital
04

Study design

Phase
Not applicable
Primary purpose
Health services research
Allocation
Randomized
Intervention model
Factorial assignment
Masking
None (open label)
Enrollment
117 participants (actual)

Study arms

  • Active comparator
    Outpatient group

    After insertion of induction catheter for labor, women of the outpatient group can go home and assess their pain with visual analogy scale at home. The intervention is to go home. Intervention for outpatient group was to go home.

    Other: Intervention for outpatient group was to go home

  • Placebo comparator
    Inpatient group

    After insertion of induction catheter for labor, women of the inpatient group assess their pain with visual analogy scale in the ward. The intervention is to stay at ward. Intervention for inpatient group was to stay at ward.

    Other: Intervention for inpatient group was to stay at ward

Interventions

  • OtherIntervention for outpatient group was to go home

    Intervention for outpatient group was to go home and assess the the pain

    Also known as: Intervention was to assess the pain by visual analogy scale.

  • OtherIntervention for inpatient group was to stay at ward

    Intervention for inpatient group was to stay at ward and assess the pain

    Also known as: Intervention was to assess the pain by visual analogy scale.

05

What researchers measure

Primary outcomes

  1. The pain measured by VAS

    The pain measured by VAS after double balloon catheter insertion.

    Time frame: one to 14 days after induction of the labor

Secondary outcomes

  1. The affect of the sleep disturbances of the mother to the pain assessed by VAS

    The affect of the sleep disturbances to the pain assessed by VAS

    Time frame: one to 14 days after induction of the labor

  2. The effect of depression of the mother to the pain assessed by VAS

    The effect of depression of the mother to the pain assessed by VAS

    Time frame: one to 14 days after induction of the labor

  3. The total hospital stay in both groups

    The total hospital stay in both groups

    Time frame: one to 14 days after induction of the labor

  4. The maternal and neonatal morbidity after balloon catheter induction

    The maternal and neonatal morbidity after balloon catheter induction

    Time frame: one to 14 days after induction of the labor

06

Study locations

1 site
  • Turku University Hospital
    Turku, 20520, Finland
07

References and documents

Publications

  • Henry A, Madan A, Reid R, Tracy SK, Austin K, Welsh A, Challis D. Outpatient Foley catheter versus inpatient prostaglandin E2 gel for induction of labour: a randomised trial. BMC Pregnancy Childbirth. 2013 Jan 29;13:25. doi: 10.1186/1471-2393-13-25. PubMed 23356673 ↗
  • Sciscione AC, Muench M, Pollock M, Jenkins TM, Tildon-Burton J, Colmorgen GH. Transcervical Foley catheter for preinduction cervical ripening in an outpatient versus inpatient setting. Obstet Gynecol. 2001 Nov;98(5 Pt 1):751-6. doi: 10.1016/s0029-7844(01)01579-4. PubMed 11704164 ↗
  • Prager M, Eneroth-Grimfors E, Edlund M, Marions L. A randomised controlled trial of intravaginal dinoprostone, intravaginal misoprostol and transcervical balloon catheter for labour induction. BJOG. 2008 Oct;115(11):1443-50. doi: 10.1111/j.1471-0528.2008.01843.x. Epub 2008 Aug 19. PubMed 18715244 ↗

Individual participant data

Plan to share: No — Letter to patients

08

Registry details

Key details

Study ID
NCT03380897
Lead sponsor
Turku University Hospital
Collaborators
University of Turku
Responsible party
Kirsi Rinne (Senior Doctor, Turku University Hospital) — Principal investigator
First posted
Dec 21, 2017
Start date
Jun 7, 2017
Primary completion
Dec 30, 2019
Completion
Dec 30, 2019
Last update
Jun 11, 2020

Study contacts

Kirsi M Rinne, PhD
principal investigator · Turku University Hospital
Päivi ML Polo, PhD
study director · Turku University Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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