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RecruitingNCT02898818Updated Sep 21, 2026

Vaginal and Oral Microbiome Crosstalk

An observational study in Healthy and Vaginal Discharge, sponsored by Turku University Hospital. Recruiting at 1 site in Finland. Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-21.

Sponsored by Turku University Hospital · Observational

From the registry’s dates

  • Started Apr 2017; still recruiting 9 years 6 months later.
Study type
Observational
Model
Cohort
Time perspective
Other
Enrollment
520
Ages
18 Years and older
Sex
Female
01

Study summary

To study the vaginal and oral microbiome by swab samples. On selected cases, also papa smear will be studied.

Read the detailed description

To study the vaginal and oral microbiome by swab samples and on selected groups, by papa smear test, to find out the constitution of normal and vaginal microbiome and the cross-talk between oral and vaginal mucosa. To find out about the impact of human papilloma virus on the microbiome and vice versa.

02

Conditions studied

  • Healthy
  • Vaginal Discharge

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03

In context

Vaginal Discharge

21 studies on the registry are indexed under Vaginal Discharge; 2 are open to participants now.

Browse Vaginal Discharge studies →

Lead sponsor

Turku University Hospital is the lead sponsor of 287 studies on the registry; 67 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
Female
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Patients coming to Turku University Hospital Dermato-Venereology Department for venereal disease tests with or without vaginal discharge. Patients coming to Turku University Hospital Gynaecology Department by remission because of atypical papa smear test result or (controls) for some other reason. Patients coming to family planning clinics in The wellbeing services county of Southwest Finland.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • patients coming to Turku University Hospital Dermato-Venereology or Gynaecology Departments or to family planning clinics in The wellbeing services county of Southwest Finland for previously mentioned reasons

Exclusion criteria

Exclusion Criteria:

  • those not meeting the criteria
05

Study design

Observational model
Cohort
Time perspective
Other
Enrollment
520 participants (estimated)
Target follow-up
5 Years
Patient registry
Yes
Biospecimen retention
Samples with dna

Groups and cohorts

  • symptomless

    vaginal and oral swab sample, questionnaire

    Other: vaginal and oral swab sample, questionnaire

  • vaginal discharge

    vaginal and oral swab sample, questionnaire

    Other: vaginal and oral swab sample, questionnaire

  • atypical papa smear

    vaginal and oral swab sample, questionnaire, papa smear

    Other: vaginal and oral swab sample, questionnaire · Other: papa smear

  • no atypical papa smear

    vaginal and oral swab sample, questionnaire, papa smear

    Other: vaginal and oral swab sample, questionnaire · Other: papa smear

  • lichen planus

    vaginal and oral swab sample, questionnaire, papa smear

    Other: vaginal and oral swab sample, questionnaire · Other: papa smear

Interventions

  • Othervaginal and oral swab sample, questionnaire

    vaginal and oral swab sample and questionnaire

  • Otherpapa smear

    Papnicolaou Papa Smear test

06

What researchers measure

Primary outcomes

  1. microbiome, papa smear

    Differences in microbiome and papa smear

    Time frame: 5 years

07

Study locations

1 of 1 sites recruiting
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Started Apr 2017 (actual). Primary completion is estimated for Sep 2027, 125 months after the start.

How these figures are worked out, and which studies are left out of them.

Registered
Sep 7, 2016
First posted
Sep 13, 2016
StartActual
Apr 19, 2017
Primary completionEst.
Sep 2027
CompletionEst.
Sep 2028
Last update
Sep 21, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Sep 21, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02898818
Collaborators
Oulu University Hospital
Responsible party
Sponsor
First posted
Sep 13, 2016
Start date
Apr 19, 2017
Primary completion
Sep 2027 (estimated)
Completion
Sep 2028 (estimated)
Last update
Sep 21, 2026

Study contacts

Niina K Hieta, MD, PhD
Contact
niina.hieta@tyks.fi
2-3131620 ext. +358-
Katja M Kero, Md, PhD
Contact
katja.kero@tyks.fi
2-3130000 ext. +358-
Niina K Hieta, MD, PhD
principal investigator · specialist

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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